Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles

The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.

Detalles Bibliográficos
Autores principales: Hamilton, Alex G., Swingle, Kelsey L., Mitchell, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231943/
https://www.ncbi.nlm.nih.gov/pubmed/37093850
http://dx.doi.org/10.1371/journal.pbio.3002105
Descripción
Sumario:The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.

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