Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles

The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.

Detalles Bibliográficos
Autores principales: Hamilton, Alex G., Swingle, Kelsey L., Mitchell, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231943/
https://www.ncbi.nlm.nih.gov/pubmed/37093850
http://dx.doi.org/10.1371/journal.pbio.3002105
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author Hamilton, Alex G.
Swingle, Kelsey L.
Mitchell, Michael J.
author_facet Hamilton, Alex G.
Swingle, Kelsey L.
Mitchell, Michael J.
author_sort Hamilton, Alex G.
collection PubMed
description The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.
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spelling pubmed-102319432023-06-01 Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles Hamilton, Alex G. Swingle, Kelsey L. Mitchell, Michael J. PLoS Biol Perspective The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic. Public Library of Science 2023-04-24 /pmc/articles/PMC10231943/ /pubmed/37093850 http://dx.doi.org/10.1371/journal.pbio.3002105 Text en © 2023 Hamilton et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Perspective
Hamilton, Alex G.
Swingle, Kelsey L.
Mitchell, Michael J.
Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
title Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
title_full Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
title_fullStr Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
title_full_unstemmed Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
title_short Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
title_sort biotechnology: overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231943/
https://www.ncbi.nlm.nih.gov/pubmed/37093850
http://dx.doi.org/10.1371/journal.pbio.3002105
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