Obesity-induced inflammation exacerbates clonal hematopoiesis

Characterized by the accumulation of somatic mutations in blood cell lineages, clonal hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the expansion of mutated hematopoietic stem and progenitor cells (HSC/Ps) that leads to an increased risk of hematologic malignancy....

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Detalles Bibliográficos
Autores principales: Pasupuleti, Santhosh Kumar, Ramdas, Baskar, Burns, Sarah S., Palam, Lakshmi Reddy, Kanumuri, Rahul, Kumar, Ramesh, Pandhiri, Taruni Reddy, Dave, Utpal P., Yellapu, Nanda Kumar, Zhou, Xinyu, Zhang, Chi, Sandusky, George E., Yu, Zhi, Honigberg, Michael C., Bick, Alexander G., Griffin, Gabriel K., Niroula, Abhishek, Ebert, Benjamin L., Paczesny, Sophie, Natarajan, Pradeep, Kapur, Reuben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231999/
https://www.ncbi.nlm.nih.gov/pubmed/37071471
http://dx.doi.org/10.1172/JCI163968

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