POLQ inhibition elicits an immune response in homologous recombination–deficient pancreatic adenocarcinoma via cGAS/STING signaling

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination–repair (HR-repair) proteins in 20%–25% of cases. Defects in HR impart a specific vulnerability to poly ADP ribose polymerase inhibitors and platinum-containing chemotherapy in tum...

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Detalles Bibliográficos
Autores principales: Oh, Grace, Wang, Annie, Wang, Lidong, Li, Jiufeng, Werba, Gregor, Weissinger, Daniel, Zhao, Ende, Dhara, Surajit, Hernandez, Rosmel E., Ackermann, Amanda, Porcella, Sarina, Kalfakakou, Despoina, Dolgalev, Igor, Kawaler, Emily, Golan, Talia, Welling, Theodore H., Sfeir, Agnel, Simeone, Diane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232002/
https://www.ncbi.nlm.nih.gov/pubmed/36976649
http://dx.doi.org/10.1172/JCI165934

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