Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy

Current therapies for Fabry disease are based on reversing intracellular accumulation of globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated stabilization of the defective enzyme, thereby alleviating lysosomal dysfunction. However, their effect in the reversal of en...

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Detalles Bibliográficos
Autores principales: Braun, Fabian, Abed, Ahmed, Sellung, Dominik, Rogg, Manuel, Woidy, Mathias, Eikrem, Oysten, Wanner, Nicola, Gambardella, Jessica, Laufer, Sandra D., Haas, Fabian, Wong, Milagros N., Dumoulin, Bernhard, Rischke, Paula, Mühlig, Anne, Sachs, Wiebke, von Cossel, Katharina, Schulz, Kristina, Muschol, Nicole, Gersting, Sören W., Muntau, Ania C., Kretz, Oliver, Hahn, Oliver, Rinschen, Markus M., Mauer, Michael, Bork, Tillmann, Grahammer, Florian, Liang, Wei, Eierhoff, Thorsten, Römer, Winfried, Hansen, Arne, Meyer-Schwesinger, Catherine, Iaccarino, Guido, Tøndel, Camilla, Marti, Hans-Peter, Najafian, Behzad, Puelles, Victor G., Schell, Christoph, Huber, Tobias B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232004/
https://www.ncbi.nlm.nih.gov/pubmed/37014703
http://dx.doi.org/10.1172/JCI157782

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