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Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies

AIMS: The present study aimed to investigate whether patients with inflammatory bowel disease (IBD) undergoing joint arthroplasty have a higher incidence of adverse outcomes than those without IBD. METHODS: A comprehensive literature search was conducted to identify eligible studies reporting postop...

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Autores principales: Xu, Dongdong, Ding, Cheng, Cheng, Tao, Yang, Chao, Zhang, Xianlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Editorial Society of Bone & Joint Surgery 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232080/
https://www.ncbi.nlm.nih.gov/pubmed/37259583
http://dx.doi.org/10.1302/2046-3758.126.BJR-2022-0394.R1
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author Xu, Dongdong
Ding, Cheng
Cheng, Tao
Yang, Chao
Zhang, Xianlong
author_facet Xu, Dongdong
Ding, Cheng
Cheng, Tao
Yang, Chao
Zhang, Xianlong
author_sort Xu, Dongdong
collection PubMed
description AIMS: The present study aimed to investigate whether patients with inflammatory bowel disease (IBD) undergoing joint arthroplasty have a higher incidence of adverse outcomes than those without IBD. METHODS: A comprehensive literature search was conducted to identify eligible studies reporting postoperative outcomes in IBD patients undergoing joint arthroplasty. The primary outcomes included postoperative complications, while the secondary outcomes included unplanned readmission, length of stay (LOS), joint reoperation/implant revision, and cost of care. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model when heterogeneity was substantial. RESULTS: Eight retrospective studies involving 29,738 patients with IBD were included. Compared with non-IBD controls, patients with IBD were significantly more likely to have overall complications (OR 2.11 (95% CI 1.67 to 2.66), p < 0.001), medical complications (OR 2.15 (95% CI 1.73 to 2.68), p < 0.001), surgical complications (OR 1.43 (95% CI 1.21 to 1.70), p < 0.001), and 90-day readmissions (OR 1.42 (95% CI 1.23 to 1.65), p < 0.001). The presence of IBD was positively associated with the development of venous thromboembolism (OR 1.60 (95% CI 1.30 to 1.97), p < 0.001) and postoperative infection (OR 1.95 (95% CI 1.51 to 2.51), p < 0.001). In addition, patients with IBD tended to experience longer LOS and higher costs of care. CONCLUSION: The findings suggest that IBD is associated with an increased risk of postoperative complications and readmission after joint arthroplasty, resulting in longer hospital stay and greater financial burden. Surgeons should inform their patients of the possibility of adverse outcomes prior to surgery and make appropriate risk adjustments to minimize potential complications. Cite this article: Bone Joint Res 2023;12(6):362–371.
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spelling pubmed-102320802023-06-01 Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies Xu, Dongdong Ding, Cheng Cheng, Tao Yang, Chao Zhang, Xianlong Bone Joint Res Arthroplasty AIMS: The present study aimed to investigate whether patients with inflammatory bowel disease (IBD) undergoing joint arthroplasty have a higher incidence of adverse outcomes than those without IBD. METHODS: A comprehensive literature search was conducted to identify eligible studies reporting postoperative outcomes in IBD patients undergoing joint arthroplasty. The primary outcomes included postoperative complications, while the secondary outcomes included unplanned readmission, length of stay (LOS), joint reoperation/implant revision, and cost of care. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model when heterogeneity was substantial. RESULTS: Eight retrospective studies involving 29,738 patients with IBD were included. Compared with non-IBD controls, patients with IBD were significantly more likely to have overall complications (OR 2.11 (95% CI 1.67 to 2.66), p < 0.001), medical complications (OR 2.15 (95% CI 1.73 to 2.68), p < 0.001), surgical complications (OR 1.43 (95% CI 1.21 to 1.70), p < 0.001), and 90-day readmissions (OR 1.42 (95% CI 1.23 to 1.65), p < 0.001). The presence of IBD was positively associated with the development of venous thromboembolism (OR 1.60 (95% CI 1.30 to 1.97), p < 0.001) and postoperative infection (OR 1.95 (95% CI 1.51 to 2.51), p < 0.001). In addition, patients with IBD tended to experience longer LOS and higher costs of care. CONCLUSION: The findings suggest that IBD is associated with an increased risk of postoperative complications and readmission after joint arthroplasty, resulting in longer hospital stay and greater financial burden. Surgeons should inform their patients of the possibility of adverse outcomes prior to surgery and make appropriate risk adjustments to minimize potential complications. Cite this article: Bone Joint Res 2023;12(6):362–371. The British Editorial Society of Bone & Joint Surgery 2023-06-01 /pmc/articles/PMC10232080/ /pubmed/37259583 http://dx.doi.org/10.1302/2046-3758.126.BJR-2022-0394.R1 Text en © 2023 Author(s) et al. https://creativecommons.org/licenses/by-nc-nd/4.0/https://online.boneandjoint.org.uk/TDMThis is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Arthroplasty
Xu, Dongdong
Ding, Cheng
Cheng, Tao
Yang, Chao
Zhang, Xianlong
Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies
title Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies
title_full Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies
title_fullStr Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies
title_full_unstemmed Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies
title_short Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies
title_sort inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty: a meta-analysis of observational studies
topic Arthroplasty
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232080/
https://www.ncbi.nlm.nih.gov/pubmed/37259583
http://dx.doi.org/10.1302/2046-3758.126.BJR-2022-0394.R1
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