Programming inactive RNA-binding small molecules into bioactive degraders

Target occupancy is often insufficient to elicit biological activity, particularly for RNA, compounded by the longstanding challenges surrounding the molecular recognition of RNA structures by small molecules. Here we studied molecular recognition patterns between a natural-product-inspired small-mo...

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Detalles Bibliográficos
Autores principales: Tong, Yuquan, Lee, Yeongju, Liu, Xiaohui, Childs-Disney, Jessica L., Suresh, Blessy M., Benhamou, Raphael I., Yang, Chunying, Li, Weimin, Costales, Matthew G., Haniff, Hafeez S., Sievers, Sonja, Abegg, Daniel, Wegner, Tristan, Paulisch, Tiffany O., Lekah, Elizabeth, Grefe, Maison, Crynen, Gogce, Van Meter, Montina, Wang, Tenghui, Gibaut, Quentin M. R., Cleveland, John L., Adibekian, Alexander, Glorius, Frank, Waldmann, Herbert, Disney, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232370/
https://www.ncbi.nlm.nih.gov/pubmed/37225982
http://dx.doi.org/10.1038/s41586-023-06091-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232370/
https://www.ncbi.nlm.nih.gov/pubmed/37225982
http://dx.doi.org/10.1038/s41586-023-06091-8

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