Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson’s disease

Parkinson’s disease (PD) is an incurable movement disorder characterized by dopaminergic cell loss, neuroinflammation, and α-synuclein pathology. Herein, we investigated the therapeutic effects of necrosulfonamide (NSA), a specific inhibitor of mixed lineage kinase domain-like protein (MLKL), in a s...

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Detalles Bibliográficos
Autores principales: Leem, Yea-Hyun, Kim, Do-Yeon, Park, Jung-Eun, Kim, Hee-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232437/
https://www.ncbi.nlm.nih.gov/pubmed/37258791
http://dx.doi.org/10.1038/s41598-023-35975-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232437/
https://www.ncbi.nlm.nih.gov/pubmed/37258791
http://dx.doi.org/10.1038/s41598-023-35975-y

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