Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia

There is a growing literature investigating the effects of selenium on the central nervous system and cognitive function. However, little is known about the role of selenoprotein P, the main selenium transporter, which can also have adverse biological effects. We conducted a prospective cohort study...

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Autores principales: Vinceti, Marco, Urbano, Teresa, Chiari, Annalisa, Filippini, Tommaso, Wise, Lauren A., Tondelli, Manuela, Michalke, Bernhard, Shimizu, Misaki, Saito, Yoshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232449/
https://www.ncbi.nlm.nih.gov/pubmed/37258587
http://dx.doi.org/10.1038/s41598-023-36084-6
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author Vinceti, Marco
Urbano, Teresa
Chiari, Annalisa
Filippini, Tommaso
Wise, Lauren A.
Tondelli, Manuela
Michalke, Bernhard
Shimizu, Misaki
Saito, Yoshiro
author_facet Vinceti, Marco
Urbano, Teresa
Chiari, Annalisa
Filippini, Tommaso
Wise, Lauren A.
Tondelli, Manuela
Michalke, Bernhard
Shimizu, Misaki
Saito, Yoshiro
author_sort Vinceti, Marco
collection PubMed
description There is a growing literature investigating the effects of selenium on the central nervous system and cognitive function. However, little is known about the role of selenoprotein P, the main selenium transporter, which can also have adverse biological effects. We conducted a prospective cohort study of individuals aged 42–81 years who received a clinical diagnosis of mild cognitive impairment. Using sandwich ELISA methods, we measured full-length selenoprotein P concentrations in serum and cerebrospinal fluid to assess the relation with dementia incidence during a median follow-up of 47.3 months. We used Cox proportional hazards regression and restricted cubic splines to model such relation. Of the 54 participants, 35 developed dementia during follow-up (including 26 cases of Alzheimer’s dementia). Selenoprotein P concentrations in serum and cerebrospinal fluid were highly correlated, and in spline regression analyses they each showed a positive non-linear association with dementia risk, particularly after excluding dementia cases diagnosed within 24 months of follow-up. We also observed differences in association according to the dementia subtypes considered. Risk ratios of dementia peaked at 2–6 at the highest levels of selenoprotein P, when compared to its median level, also depending on matrix, analytical methodology and dementia subtype. Findings of this study, the first to assess selenoprotein P levels in the central nervous system in vivo and the first to use a prospective study design to evaluate associations with dementia, suggest that higher circulating concentrations of selenoprotein P, both in serum and cerebrospinal fluid, predict progression of MCI to dementia. However, further confirmation of these findings is required, given the limited statistical precision of the associations and the potential for residual confounding.
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spelling pubmed-102324492023-06-02 Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia Vinceti, Marco Urbano, Teresa Chiari, Annalisa Filippini, Tommaso Wise, Lauren A. Tondelli, Manuela Michalke, Bernhard Shimizu, Misaki Saito, Yoshiro Sci Rep Article There is a growing literature investigating the effects of selenium on the central nervous system and cognitive function. However, little is known about the role of selenoprotein P, the main selenium transporter, which can also have adverse biological effects. We conducted a prospective cohort study of individuals aged 42–81 years who received a clinical diagnosis of mild cognitive impairment. Using sandwich ELISA methods, we measured full-length selenoprotein P concentrations in serum and cerebrospinal fluid to assess the relation with dementia incidence during a median follow-up of 47.3 months. We used Cox proportional hazards regression and restricted cubic splines to model such relation. Of the 54 participants, 35 developed dementia during follow-up (including 26 cases of Alzheimer’s dementia). Selenoprotein P concentrations in serum and cerebrospinal fluid were highly correlated, and in spline regression analyses they each showed a positive non-linear association with dementia risk, particularly after excluding dementia cases diagnosed within 24 months of follow-up. We also observed differences in association according to the dementia subtypes considered. Risk ratios of dementia peaked at 2–6 at the highest levels of selenoprotein P, when compared to its median level, also depending on matrix, analytical methodology and dementia subtype. Findings of this study, the first to assess selenoprotein P levels in the central nervous system in vivo and the first to use a prospective study design to evaluate associations with dementia, suggest that higher circulating concentrations of selenoprotein P, both in serum and cerebrospinal fluid, predict progression of MCI to dementia. However, further confirmation of these findings is required, given the limited statistical precision of the associations and the potential for residual confounding. Nature Publishing Group UK 2023-05-31 /pmc/articles/PMC10232449/ /pubmed/37258587 http://dx.doi.org/10.1038/s41598-023-36084-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Vinceti, Marco
Urbano, Teresa
Chiari, Annalisa
Filippini, Tommaso
Wise, Lauren A.
Tondelli, Manuela
Michalke, Bernhard
Shimizu, Misaki
Saito, Yoshiro
Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia
title Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia
title_full Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia
title_fullStr Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia
title_full_unstemmed Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia
title_short Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia
title_sort selenoprotein p concentrations and risk of progression from mild cognitive impairment to dementia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232449/
https://www.ncbi.nlm.nih.gov/pubmed/37258587
http://dx.doi.org/10.1038/s41598-023-36084-6
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