In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

How the genetic landscape governs a tumor’s response to immunotherapy remains poorly understood. To assess the immune-modulatory capabilities of 573 genes associated with altered cytotoxicity in human cancers, here we perform CRISPR/Cas9 screens directly in mouse lung cancer models. We recover the k...

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Detalles Bibliográficos
Autores principales: Dervovic, Dzana, Malik, Ahmad A., Chen, Edward L. Y., Narimatsu, Masahiro, Adler, Nina, Afiuni-Zadeh, Somaieh, Krenbek, Dagmar, Martinez, Sebastien, Tsai, Ricky, Boucher, Jonathan, Berman, Jacob M., Teng, Katie, Ayyaz, Arshad, Lü, YiQing, Mbamalu, Geraldine, Loganathan, Sampath K., Lee, Jongbok, Zhang, Li, Guidos, Cynthia, Wrana, Jeffrey, Valipour, Arschang, Roux, Philippe P., Reimand, Jüri, Jackson, Hartland W., Schramek, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232477/
https://www.ncbi.nlm.nih.gov/pubmed/37258521
http://dx.doi.org/10.1038/s41467-023-38841-7

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