Cargando…

Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism

Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease, had no approved pharmacological agents yet. Obeticholic acid (OCA), a novel bile acid derivative, was demonstrated to ameliorate NAFLD-related manifestations. Regarding the role of gut-liver axis in liver disease devel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jianjun, Sun, Jiayi, Yu, Jiangkun, Chen, Hang, Zhang, Dan, Zhang, Tao, Ma, Yicheng, Zou, Chenggang, Zhang, Zhigang, Ma, Lanqing, Yu, Xue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232493/ https://www.ncbi.nlm.nih.gov/pubmed/37258543 http://dx.doi.org/10.1038/s41522-023-00399-z

Ejemplares similares

The Role of Gut–Liver Axis in Gut Microbiome Dysbiosis Associated NAFLD and NAFLD-HCC
por: Song, Qian, et al.
Publicado: (2022)

Gut microbiome signatures of extreme environment adaption in Tibetan pig
por: Zhao, Fangfang, et al.
Publicado: (2023)

The Therapeutic Implications of the Gut Microbiome and Probiotics in Patients with NAFLD
por: Perumpail, Brandon J., et al.
Publicado: (2019)

Identification of 12 OCA Cases in Chinese Population and Two Novel Variants
por: Zhong, Zilin, et al.
Publicado: (2022)

Montes de Oca.
por: Pérez Galdós, Benito, 1843-1920
Publicado: (1943)

Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD
por: Smirnova, Ekaterina, et al.
Publicado: (2022)

Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives
por: Hu, Haiming, et al.
Publicado: (2019)

Gut microbiome and microbial metabolites in NAFLD and after bariatric surgery: Correlation and causality
por: Xia, Yi, et al.
Publicado: (2022)

Marco Antonio Montes de Oca
por: Montes de Oca, Marco Antonio, 1932-
Publicado: (1967)

Bile Acids: Major Regulator of the Gut Microbiome
por: An, Chihyeok, et al.
Publicado: (2022)

Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome
por: Feng, Lixing, et al.
Publicado: (2021)

Fenofibrate Improves Insulin Resistance and Hepatic Steatosis and Regulates the Let-7/SERCA2b Axis in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Mice
por: Zhang, Dan, et al.
Publicado: (2022)

Convergent and Divergent Age Patterning of Gut Microbiota Diversity in Humans and Nonhuman Primates
por: Sang, Jianan, et al.
Publicado: (2022)

Bilberry Anthocyanins Ameliorate NAFLD by Improving Dyslipidemia and Gut Microbiome Dysbiosis
por: Nakano, Hironobu, et al.
Publicado: (2020)

Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy
por: Zhang, Dan, et al.
Publicado: (2021)

The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics
por: Ridlon, Jason M., et al.
Publicado: (2015)

Diversified Shifts in the Cross Talk between Members of the Gut Microbiota and Development of Coronary Artery Diseases
por: Zhang, Tao, et al.
Publicado: (2022)

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
por: Lee, Giljae, et al.
Publicado: (2020)

The Relationship Between Gut Microbiome and Bile Acids in Primates With Diverse Diets
por: Li, Xinyue, et al.
Publicado: (2022)

Comprehensive analysis of the molecular bases of OCA in Indians
por: Ray, Kunal, et al.
Publicado: (2010)

Delineating the genetic heterogeneity of OCA in Hungarian patients
por: Fábos, Beáta, et al.
Publicado: (2017)

Rethinking the bile acid/gut microbiome axis in cancer
por: Phelan, John P., et al.
Publicado: (2017)

Physiological Role of Bile Acids Modified by the Gut Microbiome
por: Kiriyama, Yoshimitsu, et al.
Publicado: (2021)

The role of the microbiome in NAFLD and NASH
por: Kolodziejczyk, Aleksandra A, et al.
Publicado: (2018)

The contribution of the gut-liver axis to the immune signaling pathway of NAFLD
por: Liu, Jiayi, et al.
Publicado: (2022)

Delineating Novel and Known Pathogenic Variants in TYR, OCA2 and HPS-1 Genes in Eight Oculocutaneous Albinism (OCA) Pakistani Families
por: Shakil, Muhammad, et al.
Publicado: (2022)

Landscapes of gut microbiome and bile acid signatures and their interaction in HBV-associated acute-on-chronic liver failure
por: Bao, Zhiwei, et al.
Publicado: (2023)

The role of bile acid metabolism in the occurrence and development of NAFLD
por: Bing, Hao, et al.
Publicado: (2022)

Perinatal High-Salt Diet Induces Gut Microbiota Dysbiosis, Bile Acid Homeostasis Disbalance, and NAFLD in Weanling Mice Offspring
por: Guo, Qing, et al.
Publicado: (2021)

The Interplay of the Gut Microbiome, Bile Acids, and Volatile Organic Compounds
por: Sagar, Nidhi M., et al.
Publicado: (2015)

Metagenomic analysis of bile salt biotransformation in the human gut microbiome
por: Das, Promi, et al.
Publicado: (2019)

A metabolic pathway for bile acid dehydroxylation by the gut microbiome
por: Funabashi, Masanori, et al.
Publicado: (2020)

Bile Acids: Connecting Link Between Autophagy and Gut Microbiome
por: Apte, Udayan
Publicado: (2021)

Role of bile acids in liver diseases mediated by the gut microbiome
por: Shao, Jun-Wei, et al.
Publicado: (2021)

The Interaction between the Gut Microbiome and Bile Acids in Cardiometabolic Diseases
por: Callender, Cengiz, et al.
Publicado: (2022)

Gut Microbiome and Metabolites in Patients with NAFLD and after Bariatric Surgery: A Comprehensive Review
por: Hoozemans, Jacqueline, et al.
Publicado: (2021)

Tianhuang formula reduces the oxidative stress response of NAFLD by regulating the gut microbiome in mice
por: Luo, Duosheng, et al.
Publicado: (2022)

Nonhuman Primate Model of Oculocutaneous Albinism with TYR and OCA2 Mutations
por: Wu, Kun-Chao, et al.
Publicado: (2020)

Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD
por: Jiang, Xiaofan, et al.
Publicado: (2020)

Alterations of the Bile Microbiome in Recurrent Common Bile Duct Stone
por: Ye, Cheng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vqjlvupfqmk6rh6tl58fq5ftc5