Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET

INTRODUCTION: HGF/c-MET signaling is a significant driver of glioblastoma (GBM) growth and disease progression. Unfortunately, c-MET targeted therapies have been found to be largely ineffective suggesting additional redundant mechanisms of c-MET activation. METHODS: Utilizing RNA-sequencing (RNA-seq...

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Detalles Bibliográficos
Autores principales: Saunders, Jacquelyn T., Kumar, Sunil, Benavides-Serrato, Angelica, Holmes, Brent, Benavides, Kennedy E., Bashir, Muhammad T., Nishimura, Robert N., Gera, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232650/
https://www.ncbi.nlm.nih.gov/pubmed/37162666
http://dx.doi.org/10.1007/s11060-023-04331-5

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