Therapeutic strategies to enhance immune response induced by multiple myeloma cells

Multiple myeloma (MM)as a haematological malignancy is still incurable. In addition to the presence of somatic genetic mutations in myeloma patients, the presence of immunosuppressive microenvironment greatly affects the outcome of treatment. Although the discovery of immunotherapy makes it possible...

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Autores principales: Liu, Zhaoyun, Yang, Chun, Liu, Xiaohan, Xu, Xintong, Zhao, Xianghong, Fu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232766/
https://www.ncbi.nlm.nih.gov/pubmed/37275861
http://dx.doi.org/10.3389/fimmu.2023.1169541
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author Liu, Zhaoyun
Yang, Chun
Liu, Xiaohan
Xu, Xintong
Zhao, Xianghong
Fu, Rong
author_facet Liu, Zhaoyun
Yang, Chun
Liu, Xiaohan
Xu, Xintong
Zhao, Xianghong
Fu, Rong
author_sort Liu, Zhaoyun
collection PubMed
description Multiple myeloma (MM)as a haematological malignancy is still incurable. In addition to the presence of somatic genetic mutations in myeloma patients, the presence of immunosuppressive microenvironment greatly affects the outcome of treatment. Although the discovery of immunotherapy makes it possible to break the risk of high toxicity and side effects of traditional chemotherapeutic drugs, there are still obstacles of ineffective treatment or disease recurrence. In this review, we discuss therapeutic strategies to further enhance the specific anti-tumor immune response by activating the immunogenicity of MM cells themselves. New ideas for future myeloma therapeutic approaches are provided.
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spelling pubmed-102327662023-06-02 Therapeutic strategies to enhance immune response induced by multiple myeloma cells Liu, Zhaoyun Yang, Chun Liu, Xiaohan Xu, Xintong Zhao, Xianghong Fu, Rong Front Immunol Immunology Multiple myeloma (MM)as a haematological malignancy is still incurable. In addition to the presence of somatic genetic mutations in myeloma patients, the presence of immunosuppressive microenvironment greatly affects the outcome of treatment. Although the discovery of immunotherapy makes it possible to break the risk of high toxicity and side effects of traditional chemotherapeutic drugs, there are still obstacles of ineffective treatment or disease recurrence. In this review, we discuss therapeutic strategies to further enhance the specific anti-tumor immune response by activating the immunogenicity of MM cells themselves. New ideas for future myeloma therapeutic approaches are provided. Frontiers Media S.A. 2023-05-18 /pmc/articles/PMC10232766/ /pubmed/37275861 http://dx.doi.org/10.3389/fimmu.2023.1169541 Text en Copyright © 2023 Liu, Yang, Liu, Xu, Zhao and Fu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Zhaoyun
Yang, Chun
Liu, Xiaohan
Xu, Xintong
Zhao, Xianghong
Fu, Rong
Therapeutic strategies to enhance immune response induced by multiple myeloma cells
title Therapeutic strategies to enhance immune response induced by multiple myeloma cells
title_full Therapeutic strategies to enhance immune response induced by multiple myeloma cells
title_fullStr Therapeutic strategies to enhance immune response induced by multiple myeloma cells
title_full_unstemmed Therapeutic strategies to enhance immune response induced by multiple myeloma cells
title_short Therapeutic strategies to enhance immune response induced by multiple myeloma cells
title_sort therapeutic strategies to enhance immune response induced by multiple myeloma cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232766/
https://www.ncbi.nlm.nih.gov/pubmed/37275861
http://dx.doi.org/10.3389/fimmu.2023.1169541
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