Biological functions of the Olig gene family in brain cancer and therapeutic targeting

The Olig genes encode members of the basic helix–loop–helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and regulate cellular specification and differentiation. Over the past decade extensive studies hav...

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Autores principales: Szu, Jenny I., Tsigelny, Igor F., Wojcinski, Alexander, Kesari, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232966/
https://www.ncbi.nlm.nih.gov/pubmed/37274223
http://dx.doi.org/10.3389/fnins.2023.1129434
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author Szu, Jenny I.
Tsigelny, Igor F.
Wojcinski, Alexander
Kesari, Santosh
author_facet Szu, Jenny I.
Tsigelny, Igor F.
Wojcinski, Alexander
Kesari, Santosh
author_sort Szu, Jenny I.
collection PubMed
description The Olig genes encode members of the basic helix–loop–helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and regulate cellular specification and differentiation. Over the past decade extensive studies have established functional roles of Olig1 and Olig2 in development as well as in cancer. Olig2 overexpression drives glioma proliferation and resistance to radiation and chemotherapy. In this review, we summarize the biological functions of the Olig family in brain cancer and how targeting Olig family genes may have therapeutic benefit.
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spelling pubmed-102329662023-06-02 Biological functions of the Olig gene family in brain cancer and therapeutic targeting Szu, Jenny I. Tsigelny, Igor F. Wojcinski, Alexander Kesari, Santosh Front Neurosci Neuroscience The Olig genes encode members of the basic helix–loop–helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and regulate cellular specification and differentiation. Over the past decade extensive studies have established functional roles of Olig1 and Olig2 in development as well as in cancer. Olig2 overexpression drives glioma proliferation and resistance to radiation and chemotherapy. In this review, we summarize the biological functions of the Olig family in brain cancer and how targeting Olig family genes may have therapeutic benefit. Frontiers Media S.A. 2023-05-18 /pmc/articles/PMC10232966/ /pubmed/37274223 http://dx.doi.org/10.3389/fnins.2023.1129434 Text en Copyright © 2023 Szu, Tsigelny, Wojcinski and Kesari. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Szu, Jenny I.
Tsigelny, Igor F.
Wojcinski, Alexander
Kesari, Santosh
Biological functions of the Olig gene family in brain cancer and therapeutic targeting
title Biological functions of the Olig gene family in brain cancer and therapeutic targeting
title_full Biological functions of the Olig gene family in brain cancer and therapeutic targeting
title_fullStr Biological functions of the Olig gene family in brain cancer and therapeutic targeting
title_full_unstemmed Biological functions of the Olig gene family in brain cancer and therapeutic targeting
title_short Biological functions of the Olig gene family in brain cancer and therapeutic targeting
title_sort biological functions of the olig gene family in brain cancer and therapeutic targeting
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232966/
https://www.ncbi.nlm.nih.gov/pubmed/37274223
http://dx.doi.org/10.3389/fnins.2023.1129434
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