Cargando…
Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia
BACKGROUND: Discrimination of bacterial and viral etiologies of childhood community-acquired pneumonia (CAP) is often challenging. Unnecessary antibiotic administration exposes patients to undue risks and may engender antimicrobial resistance. This study aimed to develop a prediction model using epi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233046/ https://www.ncbi.nlm.nih.gov/pubmed/37275364 http://dx.doi.org/10.3389/fmed.2023.1140100 |
_version_ | 1785052145852088320 |
---|---|
author | Farida, Helmia Triasih, Rina Lokida, Dewi Mardian, Yan Salim, Gustiani Wulan, Wahyu Nawang Butar-butar, Deni P. Sari, Rizki Amalia Budiman, Arif Hayuningsih, Chakrawati Anam, Moh Syarofil Dipayana, Setya Mujahidah, Mujahidah Setyati, Amalia Aman, Abu Tholib Naysilla, Adhella Menur Lukman, Nurhayati Diana, Aly Karyana, Muhammad Kline, Ahnika Neal, Aaron Lane, H. Clifford Kosasih, Herman Lau, Chuen-Yen |
author_facet | Farida, Helmia Triasih, Rina Lokida, Dewi Mardian, Yan Salim, Gustiani Wulan, Wahyu Nawang Butar-butar, Deni P. Sari, Rizki Amalia Budiman, Arif Hayuningsih, Chakrawati Anam, Moh Syarofil Dipayana, Setya Mujahidah, Mujahidah Setyati, Amalia Aman, Abu Tholib Naysilla, Adhella Menur Lukman, Nurhayati Diana, Aly Karyana, Muhammad Kline, Ahnika Neal, Aaron Lane, H. Clifford Kosasih, Herman Lau, Chuen-Yen |
author_sort | Farida, Helmia |
collection | PubMed |
description | BACKGROUND: Discrimination of bacterial and viral etiologies of childhood community-acquired pneumonia (CAP) is often challenging. Unnecessary antibiotic administration exposes patients to undue risks and may engender antimicrobial resistance. This study aimed to develop a prediction model using epidemiological, clinical and laboratory data to differentiate between bacterial and viral CAP. METHODS: Data from 155 children with confirmed bacterial or mixed bacterial and viral infection (N = 124) and viral infection (N = 31) were derived from a comprehensive assessment of causative pathogens [Partnerships for Enhanced Engagement in Research-Pneumonia in Pediatrics (PEER-PePPeS)] conducted in Indonesia. Epidemiologic, clinical and biomarker profiles (hematology and inflammatory markers) were compared between groups. The area under the receiver operating characteristic curve (AUROC) for varying biomarker levels was used to characterize performance and determine cut-off values for discrimination of bacterial and mixed CAP versus viral CAP. Diagnostic predictors of bacterial and mixed CAP were assessed by multivariate logistic regression. RESULTS: Diarrhea was more frequently reported in bacterial and mixed CAP, while viral infections more frequently occurred during Indonesia’s rainy season. White blood cell counts (WBC), absolute neutrophil counts (ANC), neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin (PCT) were significantly higher in bacterial and mixed cases. After adjusting for covariates, the following were the most important predictors of bacterial or mixed CAP: rainy season (aOR 0.26; 95% CI 0.08–0.90; p = 0.033), CRP ≥5.70 mg/L (aOR 4.71; 95% CI 1.18–18.74; p = 0.028), and presence of fever (aOR 5.26; 95% CI 1.07–25.91; p = 0.041). The model assessed had a low R-squared (Nagelkerke R(2) = 0.490) but good calibration (p = 0.610 for Hosmer Lemeshow test). The combination of CRP and fever had moderate predictive value with sensitivity and specificity of 62.28 and 65.52%, respectively. CONCLUSION: Combining clinical and laboratory profiles is potentially valuable for discriminating bacterial and mixed from viral pediatric CAP and may guide antibiotic use. Further studies with a larger sample size should be performed to validate this model. |
format | Online Article Text |
id | pubmed-10233046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102330462023-06-02 Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia Farida, Helmia Triasih, Rina Lokida, Dewi Mardian, Yan Salim, Gustiani Wulan, Wahyu Nawang Butar-butar, Deni P. Sari, Rizki Amalia Budiman, Arif Hayuningsih, Chakrawati Anam, Moh Syarofil Dipayana, Setya Mujahidah, Mujahidah Setyati, Amalia Aman, Abu Tholib Naysilla, Adhella Menur Lukman, Nurhayati Diana, Aly Karyana, Muhammad Kline, Ahnika Neal, Aaron Lane, H. Clifford Kosasih, Herman Lau, Chuen-Yen Front Med (Lausanne) Medicine BACKGROUND: Discrimination of bacterial and viral etiologies of childhood community-acquired pneumonia (CAP) is often challenging. Unnecessary antibiotic administration exposes patients to undue risks and may engender antimicrobial resistance. This study aimed to develop a prediction model using epidemiological, clinical and laboratory data to differentiate between bacterial and viral CAP. METHODS: Data from 155 children with confirmed bacterial or mixed bacterial and viral infection (N = 124) and viral infection (N = 31) were derived from a comprehensive assessment of causative pathogens [Partnerships for Enhanced Engagement in Research-Pneumonia in Pediatrics (PEER-PePPeS)] conducted in Indonesia. Epidemiologic, clinical and biomarker profiles (hematology and inflammatory markers) were compared between groups. The area under the receiver operating characteristic curve (AUROC) for varying biomarker levels was used to characterize performance and determine cut-off values for discrimination of bacterial and mixed CAP versus viral CAP. Diagnostic predictors of bacterial and mixed CAP were assessed by multivariate logistic regression. RESULTS: Diarrhea was more frequently reported in bacterial and mixed CAP, while viral infections more frequently occurred during Indonesia’s rainy season. White blood cell counts (WBC), absolute neutrophil counts (ANC), neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin (PCT) were significantly higher in bacterial and mixed cases. After adjusting for covariates, the following were the most important predictors of bacterial or mixed CAP: rainy season (aOR 0.26; 95% CI 0.08–0.90; p = 0.033), CRP ≥5.70 mg/L (aOR 4.71; 95% CI 1.18–18.74; p = 0.028), and presence of fever (aOR 5.26; 95% CI 1.07–25.91; p = 0.041). The model assessed had a low R-squared (Nagelkerke R(2) = 0.490) but good calibration (p = 0.610 for Hosmer Lemeshow test). The combination of CRP and fever had moderate predictive value with sensitivity and specificity of 62.28 and 65.52%, respectively. CONCLUSION: Combining clinical and laboratory profiles is potentially valuable for discriminating bacterial and mixed from viral pediatric CAP and may guide antibiotic use. Further studies with a larger sample size should be performed to validate this model. Frontiers Media S.A. 2023-05-18 /pmc/articles/PMC10233046/ /pubmed/37275364 http://dx.doi.org/10.3389/fmed.2023.1140100 Text en Copyright © 2023 Farida, Triasih, Lokida, Mardian, Salim, Wulan, Butar-butar, Sari, Budiman, Hayuningsih, Anam, Dipayana, Mujahidah, Setyati, Aman, Naysilla, Lukman, Diana, Karyana, Kline, Neal, Lane, Kosasih and Lau. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Farida, Helmia Triasih, Rina Lokida, Dewi Mardian, Yan Salim, Gustiani Wulan, Wahyu Nawang Butar-butar, Deni P. Sari, Rizki Amalia Budiman, Arif Hayuningsih, Chakrawati Anam, Moh Syarofil Dipayana, Setya Mujahidah, Mujahidah Setyati, Amalia Aman, Abu Tholib Naysilla, Adhella Menur Lukman, Nurhayati Diana, Aly Karyana, Muhammad Kline, Ahnika Neal, Aaron Lane, H. Clifford Kosasih, Herman Lau, Chuen-Yen Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia |
title | Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia |
title_full | Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia |
title_fullStr | Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia |
title_full_unstemmed | Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia |
title_short | Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia |
title_sort | epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233046/ https://www.ncbi.nlm.nih.gov/pubmed/37275364 http://dx.doi.org/10.3389/fmed.2023.1140100 |
work_keys_str_mv | AT faridahelmia epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT triasihrina epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT lokidadewi epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT mardianyan epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT salimgustiani epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT wulanwahyunawang epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT butarbutardenip epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT saririzkiamalia epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT budimanarif epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT hayuningsihchakrawati epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT anammohsyarofil epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT dipayanasetya epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT mujahidahmujahidah epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT setyatiamalia epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT amanabutholib epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT naysillaadhellamenur epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT lukmannurhayati epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT dianaaly epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT karyanamuhammad epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT klineahnika epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT nealaaron epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT lanehclifford epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT kosasihherman epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia AT lauchuenyen epidemiologicclinicalandserummarkersmayimprovediscriminationbetweenbacterialandviraletiologiesofchildhoodpneumonia |