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Initially Suspected Anaphylaxis Following Iodinated Contrast: Jod-Basedow Phenomenon in a 73-Year-Old Female Without a History of Thyroid Dysfunction
The Jod-Basedow phenomenon (JB phenomenon), also referred to as “iodine-induced hyperthyroidism,” rarely occurs. Radiological imaging using iodinated contrast contains a dose of 300 to 1221 mg of iodine per kilogram, which can transiently induce clinically significant hyperthyroidism (referred to as...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233164/ https://www.ncbi.nlm.nih.gov/pubmed/37273337 http://dx.doi.org/10.7759/cureus.38415 |
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author | Adalja, Devina Kania, Brooke E Soliman, Isaac M Sanchez, Jessimar Kalatoudis, Haris |
author_facet | Adalja, Devina Kania, Brooke E Soliman, Isaac M Sanchez, Jessimar Kalatoudis, Haris |
author_sort | Adalja, Devina |
collection | PubMed |
description | The Jod-Basedow phenomenon (JB phenomenon), also referred to as “iodine-induced hyperthyroidism,” rarely occurs. Radiological imaging using iodinated contrast contains a dose of 300 to 1221 mg of iodine per kilogram, which can transiently induce clinically significant hyperthyroidism (referred to as Jod-Basedow Syndrome) in euthyroid patients. Hence, the reporting of such events is important for clinicians to be aware of, to prevent unnecessary iodine-based imaging. Underlying thyroid abnormalities, including latent Graves’ disease, autoimmune thyroiditis, use of iodine-containing foods or medications, such as amiodarone, and Lugol’s iodine have been shown to increase the risk of JB phenomenon. In terms of the pathophysiology of the JB phenomenon, when iodine exposure is in excess, increased iodine leads to increased hormone synthesis, and with an absence of auto-regulation, this can lead to thyrotoxicosis. In this case report, we describe the iodine-induced JB phenomenon in a 73-year-old female with no prior thyroid dysfunction, who was initially admitted for pyelonephritis and was eventually transferred to the intensive care unit secondary to suspected anaphylaxis. |
format | Online Article Text |
id | pubmed-10233164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-102331642023-06-02 Initially Suspected Anaphylaxis Following Iodinated Contrast: Jod-Basedow Phenomenon in a 73-Year-Old Female Without a History of Thyroid Dysfunction Adalja, Devina Kania, Brooke E Soliman, Isaac M Sanchez, Jessimar Kalatoudis, Haris Cureus Endocrinology/Diabetes/Metabolism The Jod-Basedow phenomenon (JB phenomenon), also referred to as “iodine-induced hyperthyroidism,” rarely occurs. Radiological imaging using iodinated contrast contains a dose of 300 to 1221 mg of iodine per kilogram, which can transiently induce clinically significant hyperthyroidism (referred to as Jod-Basedow Syndrome) in euthyroid patients. Hence, the reporting of such events is important for clinicians to be aware of, to prevent unnecessary iodine-based imaging. Underlying thyroid abnormalities, including latent Graves’ disease, autoimmune thyroiditis, use of iodine-containing foods or medications, such as amiodarone, and Lugol’s iodine have been shown to increase the risk of JB phenomenon. In terms of the pathophysiology of the JB phenomenon, when iodine exposure is in excess, increased iodine leads to increased hormone synthesis, and with an absence of auto-regulation, this can lead to thyrotoxicosis. In this case report, we describe the iodine-induced JB phenomenon in a 73-year-old female with no prior thyroid dysfunction, who was initially admitted for pyelonephritis and was eventually transferred to the intensive care unit secondary to suspected anaphylaxis. Cureus 2023-05-01 /pmc/articles/PMC10233164/ /pubmed/37273337 http://dx.doi.org/10.7759/cureus.38415 Text en Copyright © 2023, Adalja et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Adalja, Devina Kania, Brooke E Soliman, Isaac M Sanchez, Jessimar Kalatoudis, Haris Initially Suspected Anaphylaxis Following Iodinated Contrast: Jod-Basedow Phenomenon in a 73-Year-Old Female Without a History of Thyroid Dysfunction |
title | Initially Suspected Anaphylaxis Following Iodinated Contrast: Jod-Basedow Phenomenon in a 73-Year-Old Female Without a History of Thyroid Dysfunction |
title_full | Initially Suspected Anaphylaxis Following Iodinated Contrast: Jod-Basedow Phenomenon in a 73-Year-Old Female Without a History of Thyroid Dysfunction |
title_fullStr | Initially Suspected Anaphylaxis Following Iodinated Contrast: Jod-Basedow Phenomenon in a 73-Year-Old Female Without a History of Thyroid Dysfunction |
title_full_unstemmed | Initially Suspected Anaphylaxis Following Iodinated Contrast: Jod-Basedow Phenomenon in a 73-Year-Old Female Without a History of Thyroid Dysfunction |
title_short | Initially Suspected Anaphylaxis Following Iodinated Contrast: Jod-Basedow Phenomenon in a 73-Year-Old Female Without a History of Thyroid Dysfunction |
title_sort | initially suspected anaphylaxis following iodinated contrast: jod-basedow phenomenon in a 73-year-old female without a history of thyroid dysfunction |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233164/ https://www.ncbi.nlm.nih.gov/pubmed/37273337 http://dx.doi.org/10.7759/cureus.38415 |
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