Cargando…

Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration

Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R) (also known as ATGL). PEDF-R exhibits phospholipase activity that mediates the neurotrophic action of its ligand PEDF. Because phospholipids...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernardo-Colón, Alexandra, Dong, Lijin, Abu-Asab, Mones, Brush, Richard S., Agbaga, Martin-Paul, Becerra, S. Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233210/ https://www.ncbi.nlm.nih.gov/pubmed/36934843 http://dx.doi.org/10.1016/j.jlr.2023.100358

Ejemplares similares

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R)
por: Bullock, Jeanee, et al.
Publicado: (2021)

Pigment Epithelium-Derived Factor (PEDF) Fragments Prevent Mouse Cone Photoreceptor Cell Loss Induced by Focal Phototoxicity In Vivo
por: Valiente-Soriano, Francisco J., et al.
Publicado: (2020)

NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration
por: Wang, Yujuan, et al.
Publicado: (2016)

Pigment epithelium-derived factor hinders photoreceptor cell death by reducing intracellular calcium in the degenerating retina
por: Comitato, Antonella, et al.
Publicado: (2018)

Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis
por: Michalczyk, Elizabeth R., et al.
Publicado: (2018)

Pigment epithelium-derived factor is an interleukin-6 antagonist in the RPE: Insight of structure-function relationships
por: Bernardo-Colón, Alexandra, et al.
Publicado: (2022)

Pigment Epithelium‐Derived Factor (PEDF) Improves Ischemic Cardiac Functional Reserve Through Decreasing Hypoxic Cardiomyocyte Contractility Through PEDF Receptor (PEDF‐R)
por: Lu, Peng, et al.
Publicado: (2016)

Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons
por: Bürger, Susanne, et al.
Publicado: (2020)

Scaffold-Free Retinal Pigment Epithelium Microtissues Exhibit Increased Release of PEDF
por: Al-Ani, Abdullah, et al.
Publicado: (2021)

Pigment Epithelium-Derived Factor (PEDF) Protects Osteoblastic Cell Line from Glucocorticoid-Induced Apoptosis via PEDF-R
por: Yao, Shengcheng, et al.
Publicado: (2016)

Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse
por: Schori, Christian, et al.
Publicado: (2018)

Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver
por: Protiva, Petr, et al.
Publicado: (2015)

Photoreceptor degeneration in microphthalmia (Mitf) mice: partial rescue by pigment epithelium-derived factor
por: Chen, Yu, et al.
Publicado: (2019)

Relationship between pigment epithelium-derived factor (PEDF) and renal function in patients with diabetic retinopathy
por: Matsuyama, Kayako, et al.
Publicado: (2008)

Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies
por: Cheng, Shun-Yun, et al.
Publicado: (2020)

HK2 Mediated Glycolytic Metabolism in Mouse Photoreceptors Is Not Required to Cause Late Stage Age-Related Macular Degeneration-Like Pathologies
por: Cheng, Shun-Yun, et al.
Publicado: (2021)

Novel Localization of Peripherin 2, the Photoreceptor-Specific Retinal Degeneration Slow Protein, in Retinal Pigment Epithelium
por: Uhl, Patrizia B., et al.
Publicado: (2015)

Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa
por: Mercau, Maria E., et al.
Publicado: (2023)

The Expression Levels and Cellular Localization of Pigment Epithelium Derived Factor (PEDF) in Mouse Testis: Its Possible Involvement in the Differentiation of Spermatogonial Cells
por: Bagdadi, Noy, et al.
Publicado: (2021)

Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review
por: Belkacemi, Louiza, et al.
Publicado: (2016)

Focal electroretinogram and microperimetry testing of photoreceptor‐retinal pigment epithelium function in intermediate age‐related macular degeneration
por: Messenio, Dario, et al.
Publicado: (2021)

Cigarette Smoke-Related Hydroquinone Dysregulates MCP-1, VEGF and PEDF Expression in Retinal Pigment Epithelium in Vitro and in Vivo
por: Pons, Marianne, et al.
Publicado: (2011)

Delayed Treatment with a Small Pigment Epithelium Derived Factor (PEDF) Peptide Prevents the Progression of Diabetic Renal Injury
por: Awad, Alaa S., et al.
Publicado: (2015)

Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions
por: Nakamura, Daisy S., et al.
Publicado: (2017)

Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease
por: Sagheer, Usman, et al.
Publicado: (2015)

Inflammation and Cell Death in Age-Related Macular Degeneration: An Immunopathological and Ultrastructural Model
por: Ardeljan, Christopher P., et al.
Publicado: (2014)

The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration
por: Agbaga, Martin-Paul, et al.
Publicado: (2020)

Decreased VEGF-A and sustained PEDF expression in a human retinal pigment epithelium cell line cultured under hypothermia
por: Takeyama, Masayuki, et al.
Publicado: (2015)

Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules
por: Windschüttl, S., et al.
Publicado: (2015)

Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI
por: Belinsky, Glenn S., et al.
Publicado: (2016)

Pigment epithelium derived factor (PEDF) prevents methyl methacrylate monomer-induced cytotoxicity in H9c2 cells
por: Xin, Li, et al.
Publicado: (2017)

Pigment epithelium-derived factor (PEDF): a novel trophoblast-derived factor limiting feto-placental angiogenesis in late pregnancy
por: Loegl, Jelena, et al.
Publicado: (2016)

The Retinal Pigment Epithelium: a Convenient Source of New Photoreceptor cells?
por: Wang, Shu-Zhen, et al.
Publicado: (2014)

Retinal Pigment Epithelium and Photoreceptor Preconditioning Protection Requires Docosanoid Signaling
por: Knott, Eric J., et al.
Publicado: (2017)

PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE
por: Rebustini, Ivan T., et al.
Publicado: (2022)

In vitro disease modeling of oculocutaneous albinism type 1 and 2 using human induced pluripotent stem cell-derived retinal pigment epithelium
por: George, Aman, et al.
Publicado: (2022)

Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells
por: Yin, Jinlong, et al.
Publicado: (2015)

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration
por: Storm, Tina, et al.
Publicado: (2019)

Cell-autonomous lipid-handling defects in Stargardt iPSC-derived retinal pigment epithelium cells
por: Farnoodian, Mitra, et al.
Publicado: (2022)

Pigment Epithelium-Derived Factor (PEDF) Interacts with Transportin SR2, and Active Nuclear Import Is Facilitated by a Novel Nuclear Localization Motif
por: Anguissola, Sergio, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_egi6ea02b72c1qon0v8222alir