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Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure

Prenatal alcohol exposure (PAE) can change the normal trajectory of human fetal brain development and may lead to long-lasting neurodevelopmental changes in the form of fetal alcohol spectrum disorders. Currently, early prenatal patterns of alcohol-related central nervous system changes are unclear...

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Autores principales: Stuempflen, Marlene, Schwartz, Ernst, Diogo, Mariana C, Glatter, Sarah, Pfeiler, Birgit, Kienast, Patric, Taymourtash, Athena, Schmidbauer, Victor U, Bartha-Doering, Lisa, Krampl-Bettelheim, Elisabeth, Seidl, Rainer, Langs, Georg, Prayer, Daniela, Kasprian, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233241/
https://www.ncbi.nlm.nih.gov/pubmed/36807411
http://dx.doi.org/10.1093/cercor/bhad005
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author Stuempflen, Marlene
Schwartz, Ernst
Diogo, Mariana C
Glatter, Sarah
Pfeiler, Birgit
Kienast, Patric
Taymourtash, Athena
Schmidbauer, Victor U
Bartha-Doering, Lisa
Krampl-Bettelheim, Elisabeth
Seidl, Rainer
Langs, Georg
Prayer, Daniela
Kasprian, Gregor
author_facet Stuempflen, Marlene
Schwartz, Ernst
Diogo, Mariana C
Glatter, Sarah
Pfeiler, Birgit
Kienast, Patric
Taymourtash, Athena
Schmidbauer, Victor U
Bartha-Doering, Lisa
Krampl-Bettelheim, Elisabeth
Seidl, Rainer
Langs, Georg
Prayer, Daniela
Kasprian, Gregor
author_sort Stuempflen, Marlene
collection PubMed
description Prenatal alcohol exposure (PAE) can change the normal trajectory of human fetal brain development and may lead to long-lasting neurodevelopmental changes in the form of fetal alcohol spectrum disorders. Currently, early prenatal patterns of alcohol-related central nervous system changes are unclear and it is unknown if small amounts of PAE may result in early detectable brain anomalies. This super-resolution fetal magnetic resonance imaging (MRI) study aimed to identify regional effects of PAE on human brain structure. Fetuses were prospectively assessed using atlas-based semi-automated 3-dimensional tissue segmentation based on 1.5 T and 3 T fetal brain MRI examinations. After expectant mothers completed anonymized PRAMS and TACE questionnaires for PAE, fetuses without gross macroscopic brain abnormalities were identified and analyzed. Linear mixed-effects modeling of regional brain volumes was conducted and multiple comparisons were corrected using the Benjamini–Hochberg procedure. In total, 500 pregnant women were recruited with 51 reporting gestational alcohol consumption. After excluding confounding comorbidities, 24 fetuses (26 observations) were identified with PAE and 52 age-matched controls without PAE were analyzed. Patients with PAE showed significantly larger volumes of the corpus callosum (P ≤ 0.001) and smaller volumes of the periventricular zone (P = 0.001). Even minor (1–3 standard drinks per week) PAE changed the neurodevelopmental trajectory.
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spelling pubmed-102332412023-06-02 Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure Stuempflen, Marlene Schwartz, Ernst Diogo, Mariana C Glatter, Sarah Pfeiler, Birgit Kienast, Patric Taymourtash, Athena Schmidbauer, Victor U Bartha-Doering, Lisa Krampl-Bettelheim, Elisabeth Seidl, Rainer Langs, Georg Prayer, Daniela Kasprian, Gregor Cereb Cortex Original Article Prenatal alcohol exposure (PAE) can change the normal trajectory of human fetal brain development and may lead to long-lasting neurodevelopmental changes in the form of fetal alcohol spectrum disorders. Currently, early prenatal patterns of alcohol-related central nervous system changes are unclear and it is unknown if small amounts of PAE may result in early detectable brain anomalies. This super-resolution fetal magnetic resonance imaging (MRI) study aimed to identify regional effects of PAE on human brain structure. Fetuses were prospectively assessed using atlas-based semi-automated 3-dimensional tissue segmentation based on 1.5 T and 3 T fetal brain MRI examinations. After expectant mothers completed anonymized PRAMS and TACE questionnaires for PAE, fetuses without gross macroscopic brain abnormalities were identified and analyzed. Linear mixed-effects modeling of regional brain volumes was conducted and multiple comparisons were corrected using the Benjamini–Hochberg procedure. In total, 500 pregnant women were recruited with 51 reporting gestational alcohol consumption. After excluding confounding comorbidities, 24 fetuses (26 observations) were identified with PAE and 52 age-matched controls without PAE were analyzed. Patients with PAE showed significantly larger volumes of the corpus callosum (P ≤ 0.001) and smaller volumes of the periventricular zone (P = 0.001). Even minor (1–3 standard drinks per week) PAE changed the neurodevelopmental trajectory. Oxford University Press 2023-02-17 /pmc/articles/PMC10233241/ /pubmed/36807411 http://dx.doi.org/10.1093/cercor/bhad005 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Stuempflen, Marlene
Schwartz, Ernst
Diogo, Mariana C
Glatter, Sarah
Pfeiler, Birgit
Kienast, Patric
Taymourtash, Athena
Schmidbauer, Victor U
Bartha-Doering, Lisa
Krampl-Bettelheim, Elisabeth
Seidl, Rainer
Langs, Georg
Prayer, Daniela
Kasprian, Gregor
Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure
title Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure
title_full Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure
title_fullStr Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure
title_full_unstemmed Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure
title_short Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure
title_sort fetal mri based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233241/
https://www.ncbi.nlm.nih.gov/pubmed/36807411
http://dx.doi.org/10.1093/cercor/bhad005
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