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Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults

This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data were acquired from 81 healthy adults with normal sleep (41 females, age 20.96–39.58 years) during a test of cognitive control (Not-X-CPT). Sleep heal...

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Autores principales: Smevik, Hanne, Habli, Sarah, Saksvik, Simen Berg, Kliem, Elisabeth, Evensmoen, Hallvard Røe, Conde, Virginia, Petroni, Agustin, Asarnow, Robert F, Dennis, Emily L, Eikenes, Live, Kallestad, Håvard, Sand, Trond, Thompson, Paul M, Saksvik-Lehouillier, Ingvild, Håberg, Asta Kristine, Olsen, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233256/
https://www.ncbi.nlm.nih.gov/pubmed/36790738
http://dx.doi.org/10.1093/cercor/bhad024
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author Smevik, Hanne
Habli, Sarah
Saksvik, Simen Berg
Kliem, Elisabeth
Evensmoen, Hallvard Røe
Conde, Virginia
Petroni, Agustin
Asarnow, Robert F
Dennis, Emily L
Eikenes, Live
Kallestad, Håvard
Sand, Trond
Thompson, Paul M
Saksvik-Lehouillier, Ingvild
Håberg, Asta Kristine
Olsen, Alexander
author_facet Smevik, Hanne
Habli, Sarah
Saksvik, Simen Berg
Kliem, Elisabeth
Evensmoen, Hallvard Røe
Conde, Virginia
Petroni, Agustin
Asarnow, Robert F
Dennis, Emily L
Eikenes, Live
Kallestad, Håvard
Sand, Trond
Thompson, Paul M
Saksvik-Lehouillier, Ingvild
Håberg, Asta Kristine
Olsen, Alexander
author_sort Smevik, Hanne
collection PubMed
description This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data were acquired from 81 healthy adults with normal sleep (41 females, age 20.96–39.58 years) during a test of cognitive control (Not-X-CPT). Sleep health was assessed in the week before MRI scanning, using both objective (actigraphy) and self-report measures. Multiple measures indicating poorer sleep health—including later/more variable sleep timing, later chronotype preference, more insomnia symptoms, and lower sleep efficiency—were associated with stronger and more widespread BOLD activations in fronto-parietal and subcortical brain regions during cognitive control processing (adjusted for age, sex, education, and fMRI task performance). Most associations were found for reactive cognitive control activation, indicating that poorer sleep health is linked to a “hyper-reactive” brain state. Analysis of time-on-task effects showed that, with longer time on task, poorer sleep health was predominantly associated with increased proactive cognitive control activation, indicating recruitment of additional neural resources over time. Finally, shorter objective sleep duration was associated with lower BOLD activation with time on task and poorer task performance. In conclusion, even in “normal sleepers,” relatively poorer sleep health is associated with altered cognitive control processing, possibly reflecting compensatory mechanisms and/or inefficient neural processing.
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spelling pubmed-102332562023-06-02 Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults Smevik, Hanne Habli, Sarah Saksvik, Simen Berg Kliem, Elisabeth Evensmoen, Hallvard Røe Conde, Virginia Petroni, Agustin Asarnow, Robert F Dennis, Emily L Eikenes, Live Kallestad, Håvard Sand, Trond Thompson, Paul M Saksvik-Lehouillier, Ingvild Håberg, Asta Kristine Olsen, Alexander Cereb Cortex Original Article This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data were acquired from 81 healthy adults with normal sleep (41 females, age 20.96–39.58 years) during a test of cognitive control (Not-X-CPT). Sleep health was assessed in the week before MRI scanning, using both objective (actigraphy) and self-report measures. Multiple measures indicating poorer sleep health—including later/more variable sleep timing, later chronotype preference, more insomnia symptoms, and lower sleep efficiency—were associated with stronger and more widespread BOLD activations in fronto-parietal and subcortical brain regions during cognitive control processing (adjusted for age, sex, education, and fMRI task performance). Most associations were found for reactive cognitive control activation, indicating that poorer sleep health is linked to a “hyper-reactive” brain state. Analysis of time-on-task effects showed that, with longer time on task, poorer sleep health was predominantly associated with increased proactive cognitive control activation, indicating recruitment of additional neural resources over time. Finally, shorter objective sleep duration was associated with lower BOLD activation with time on task and poorer task performance. In conclusion, even in “normal sleepers,” relatively poorer sleep health is associated with altered cognitive control processing, possibly reflecting compensatory mechanisms and/or inefficient neural processing. Oxford University Press 2023-02-14 /pmc/articles/PMC10233256/ /pubmed/36790738 http://dx.doi.org/10.1093/cercor/bhad024 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Smevik, Hanne
Habli, Sarah
Saksvik, Simen Berg
Kliem, Elisabeth
Evensmoen, Hallvard Røe
Conde, Virginia
Petroni, Agustin
Asarnow, Robert F
Dennis, Emily L
Eikenes, Live
Kallestad, Håvard
Sand, Trond
Thompson, Paul M
Saksvik-Lehouillier, Ingvild
Håberg, Asta Kristine
Olsen, Alexander
Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults
title Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults
title_full Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults
title_fullStr Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults
title_full_unstemmed Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults
title_short Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults
title_sort poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233256/
https://www.ncbi.nlm.nih.gov/pubmed/36790738
http://dx.doi.org/10.1093/cercor/bhad024
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