Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors

We report on liver transplantation in two patients with GSD Ib on treatment with empagliflozin. The use of this SGLT2 inhibitor resulted in a marked decrease of 1,5-anhydroglucitol which has an important role in the development of neutropenia in this condition. As intended, this caused a significant...

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Detalles Bibliográficos
Autores principales: Murko, Simona, Peschka, Manuela, Tsiakas, Konstantinos, Schulz-Jürgensen, Sebastian, Herden, Uta, Santer, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233270/
https://www.ncbi.nlm.nih.gov/pubmed/37275680
http://dx.doi.org/10.1016/j.ymgmr.2023.100977
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author Murko, Simona
Peschka, Manuela
Tsiakas, Konstantinos
Schulz-Jürgensen, Sebastian
Herden, Uta
Santer, René
author_facet Murko, Simona
Peschka, Manuela
Tsiakas, Konstantinos
Schulz-Jürgensen, Sebastian
Herden, Uta
Santer, René
author_sort Murko, Simona
collection PubMed
description We report on liver transplantation in two patients with GSD Ib on treatment with empagliflozin. The use of this SGLT2 inhibitor resulted in a marked decrease of 1,5-anhydroglucitol which has an important role in the development of neutropenia in this condition. As intended, this caused a significant rise of neutrophil numbers. Liver transplantation alone did not produce the desired effect and our observation argues for continuing SGLT2 inhibitor treatment after transplantation.
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spelling pubmed-102332702023-06-02 Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors Murko, Simona Peschka, Manuela Tsiakas, Konstantinos Schulz-Jürgensen, Sebastian Herden, Uta Santer, René Mol Genet Metab Rep Short Communication We report on liver transplantation in two patients with GSD Ib on treatment with empagliflozin. The use of this SGLT2 inhibitor resulted in a marked decrease of 1,5-anhydroglucitol which has an important role in the development of neutropenia in this condition. As intended, this caused a significant rise of neutrophil numbers. Liver transplantation alone did not produce the desired effect and our observation argues for continuing SGLT2 inhibitor treatment after transplantation. Elsevier 2023-05-04 /pmc/articles/PMC10233270/ /pubmed/37275680 http://dx.doi.org/10.1016/j.ymgmr.2023.100977 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Murko, Simona
Peschka, Manuela
Tsiakas, Konstantinos
Schulz-Jürgensen, Sebastian
Herden, Uta
Santer, René
Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors
title Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors
title_full Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors
title_fullStr Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors
title_full_unstemmed Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors
title_short Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors
title_sort liver transplantation in glycogen storage disease type ib: the role of sglt2 inhibitors
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233270/
https://www.ncbi.nlm.nih.gov/pubmed/37275680
http://dx.doi.org/10.1016/j.ymgmr.2023.100977
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