Breaking bad

DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20221086) develop D1(−/−), D1L3(−/−), and D1(−/−)D1L3(−/−) mice to show that exogenous additi...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Mohini, Horswill, Alexander R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233462/
https://www.ncbi.nlm.nih.gov/pubmed/37129875
http://dx.doi.org/10.1084/jem.20230421
Descripción
Sumario:DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20221086) develop D1(−/−), D1L3(−/−), and D1(−/−)D1L3(−/−) mice to show that exogenous addition of the DNase formulation Dornase alfa can facilitate removal of biofilms.

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