Breaking bad

DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20221086) develop D1(−/−), D1L3(−/−), and D1(−/−)D1L3(−/−) mice to show that exogenous additi...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Mohini, Horswill, Alexander R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233462/
https://www.ncbi.nlm.nih.gov/pubmed/37129875
http://dx.doi.org/10.1084/jem.20230421
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author Bhattacharya, Mohini
Horswill, Alexander R.
author_facet Bhattacharya, Mohini
Horswill, Alexander R.
author_sort Bhattacharya, Mohini
collection PubMed
description DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20221086) develop D1(−/−), D1L3(−/−), and D1(−/−)D1L3(−/−) mice to show that exogenous addition of the DNase formulation Dornase alfa can facilitate removal of biofilms.
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spelling pubmed-102334622023-11-02 Breaking bad Bhattacharya, Mohini Horswill, Alexander R. J Exp Med Insights DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20221086) develop D1(−/−), D1L3(−/−), and D1(−/−)D1L3(−/−) mice to show that exogenous addition of the DNase formulation Dornase alfa can facilitate removal of biofilms. Rockefeller University Press 2023-05-02 /pmc/articles/PMC10233462/ /pubmed/37129875 http://dx.doi.org/10.1084/jem.20230421 Text en © 2023 Bhattacharya and Horswill https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Bhattacharya, Mohini
Horswill, Alexander R.
Breaking bad
title Breaking bad
title_full Breaking bad
title_fullStr Breaking bad
title_full_unstemmed Breaking bad
title_short Breaking bad
title_sort breaking bad
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233462/
https://www.ncbi.nlm.nih.gov/pubmed/37129875
http://dx.doi.org/10.1084/jem.20230421
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