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ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade

BACKGROUND: Inducible T cell costimulator ICOS is an emerging target in immuno-oncology. The aim of this study was to investigate the epigenetic regulation of ICOS in melanoma by DNA methylation. METHODS: We comprehensively investigate ICOS DNA methylation of specific CpG sites and expression patter...

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Detalles Bibliográficos
Autores principales:	Ralser, Damian J., Herr, Emmanuelle, de Vos, Luka, Kulcsár, Zsófi, Zarbl, Romina, Klümper, Niklas, Gielen, Gerrit H., Maas, Alexander Philippe, Hoffmann, Friederike, Dietrich, Jörn, Kuster, Pia, Mustea, Alexander, Glodde, Nicole, Kristiansen, Glen, Strieth, Sebastian, Landsberg, Jennifer, Dietrich, Dimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233860/ https://www.ncbi.nlm.nih.gov/pubmed/37259155 http://dx.doi.org/10.1186/s40364-023-00508-2

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