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A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection

PURPOSE: To observe long-term prognosis of anterior segment ischemia (ASI) following hyaluronic acid (HA) injection, propose a severity grading system for ASI and a predictive model for phthisis bulbi (PB) based on long-term secretion dysfunction of ciliary process. METHODS: This is a retrospective...

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Autores principales: Si, Shancheng, Su, Wei, Wang, Lei, Ji, Yicong, Chen, Anming, Hu, Yuntao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233880/
https://www.ncbi.nlm.nih.gov/pubmed/37259051
http://dx.doi.org/10.1186/s12886-023-02992-4
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author Si, Shancheng
Su, Wei
Wang, Lei
Ji, Yicong
Chen, Anming
Hu, Yuntao
author_facet Si, Shancheng
Su, Wei
Wang, Lei
Ji, Yicong
Chen, Anming
Hu, Yuntao
author_sort Si, Shancheng
collection PubMed
description PURPOSE: To observe long-term prognosis of anterior segment ischemia (ASI) following hyaluronic acid (HA) injection, propose a severity grading system for ASI and a predictive model for phthisis bulbi (PB) based on long-term secretion dysfunction of ciliary process. METHODS: This is a retrospective case–control study. All enrolled 20 patients were divided into two groups and followed for at least 6 months to observe the formation and transformation characteristics of ASI and long-term prognosis based on the degrees of ciliary function damage. RESULTS: The severity of ASI following HA injection could be subdivided into 4 grades according to the degrees of ciliary function damage, comprising ASI grades 0, 1, 2 and 3. In 20 patients, ophthalmoplegia at 1-month follow-up, ASI within 1 month, ASI at 1-month follow-up, hypotony within 6 months were all significantly more common in study group than in control group (60% vs. 0%, P = 0.011; 100% vs. 20%, P = 0.001; 100% vs. 0%, P < 0.001; 80% vs. 0%, P = 0.001, respectively). Sensitivity, specificity and the area under the receiver operating characteristic curve (AUC) for predicting subsequent PB at 2-year follow-up through the co-occurrence of ophthalmoplegia at 1-month follow-up and hypotony within 6 months was 100%, 100% and 1.00, respectively. CONCLUSIONS: The new grading system for ASI and novel predictive model for PB we proposed could predict the long-term prognosis and probability of subsequent PB due to ASI following HA injection through several dynamic assessments within 6 months. LEVEL OF EVIDENCE: Level IV, observational prognostic study.
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spelling pubmed-102338802023-06-02 A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection Si, Shancheng Su, Wei Wang, Lei Ji, Yicong Chen, Anming Hu, Yuntao BMC Ophthalmol Research Article PURPOSE: To observe long-term prognosis of anterior segment ischemia (ASI) following hyaluronic acid (HA) injection, propose a severity grading system for ASI and a predictive model for phthisis bulbi (PB) based on long-term secretion dysfunction of ciliary process. METHODS: This is a retrospective case–control study. All enrolled 20 patients were divided into two groups and followed for at least 6 months to observe the formation and transformation characteristics of ASI and long-term prognosis based on the degrees of ciliary function damage. RESULTS: The severity of ASI following HA injection could be subdivided into 4 grades according to the degrees of ciliary function damage, comprising ASI grades 0, 1, 2 and 3. In 20 patients, ophthalmoplegia at 1-month follow-up, ASI within 1 month, ASI at 1-month follow-up, hypotony within 6 months were all significantly more common in study group than in control group (60% vs. 0%, P = 0.011; 100% vs. 20%, P = 0.001; 100% vs. 0%, P < 0.001; 80% vs. 0%, P = 0.001, respectively). Sensitivity, specificity and the area under the receiver operating characteristic curve (AUC) for predicting subsequent PB at 2-year follow-up through the co-occurrence of ophthalmoplegia at 1-month follow-up and hypotony within 6 months was 100%, 100% and 1.00, respectively. CONCLUSIONS: The new grading system for ASI and novel predictive model for PB we proposed could predict the long-term prognosis and probability of subsequent PB due to ASI following HA injection through several dynamic assessments within 6 months. LEVEL OF EVIDENCE: Level IV, observational prognostic study. BioMed Central 2023-05-31 /pmc/articles/PMC10233880/ /pubmed/37259051 http://dx.doi.org/10.1186/s12886-023-02992-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Si, Shancheng
Su, Wei
Wang, Lei
Ji, Yicong
Chen, Anming
Hu, Yuntao
A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection
title A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection
title_full A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection
title_fullStr A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection
title_full_unstemmed A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection
title_short A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection
title_sort novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233880/
https://www.ncbi.nlm.nih.gov/pubmed/37259051
http://dx.doi.org/10.1186/s12886-023-02992-4
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