Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia

Frontotemporal dementia (FTD) is the second most prevalent type of early-onset dementia and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B, which encodes a protein found in a complex important for maturation of late endosomes, an essential process for recycling...

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Detalles Bibliográficos
Autores principales: Canals, Isaac, Comella-Bolla, Andrea, Cepeda-Prado, Efrain, Avaliani, Natalia, Crowe, James A, Oburoglu, Leal, Bruzelius, Andreas, King, Naomi, Pajares, María A, Pérez-Sala, Dolores, Heuer, Andreas, Rylander Ottosson, Daniella, Soriano, Jordi, Ahlenius, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233896/
https://www.ncbi.nlm.nih.gov/pubmed/37274831
http://dx.doi.org/10.1093/braincomms/fcad158

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