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Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo

Adenosine to inosine editing (A-to-I) in regions of double stranded RNA (dsRNA) is mediated by adenosine deaminase acting on RNA 1 (ADAR1) or ADAR2. ADAR1 and A-to-I editing levels are increased in many human cancers. Inhibition of ADAR1 has emerged as a high priority oncology target, however, wheth...

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Detalles Bibliográficos
Autores principales:	Mendez Ruiz, Shannon, Chalk, Alistair M, Goradia, Ankita, Heraud-Farlow, Jacki, Walkley, Carl R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Cancer-specific RNAs and RNA Processing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233902/ https://www.ncbi.nlm.nih.gov/pubmed/37275274 http://dx.doi.org/10.1093/narcan/zcad023

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