The role of m6A methylation in therapy resistance in cancer

Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA metabolism, such as stability, splicing, transcrip...

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Autores principales: Zhuang, Hengzhao, Yu, Bo, Tao, Dan, Xu, Xiaoyan, Xu, Yijun, Wang, Jian, Jiao, Yang, Wang, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233906/
https://www.ncbi.nlm.nih.gov/pubmed/37264402
http://dx.doi.org/10.1186/s12943-023-01782-2
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author Zhuang, Hengzhao
Yu, Bo
Tao, Dan
Xu, Xiaoyan
Xu, Yijun
Wang, Jian
Jiao, Yang
Wang, Lili
author_facet Zhuang, Hengzhao
Yu, Bo
Tao, Dan
Xu, Xiaoyan
Xu, Yijun
Wang, Jian
Jiao, Yang
Wang, Lili
author_sort Zhuang, Hengzhao
collection PubMed
description Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA metabolism, such as stability, splicing, transcription, translation, and degradation. A large number of studies have shown that m6A RNA methylation regulates the proliferation and invasion of cancer cells, but the role of m6A in cancer therapy resistance is unclear. In this review, we summarized the research progress related to the role of m6A in regulating therapy resistance in cancers.
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spelling pubmed-102339062023-06-02 The role of m6A methylation in therapy resistance in cancer Zhuang, Hengzhao Yu, Bo Tao, Dan Xu, Xiaoyan Xu, Yijun Wang, Jian Jiao, Yang Wang, Lili Mol Cancer Review Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA metabolism, such as stability, splicing, transcription, translation, and degradation. A large number of studies have shown that m6A RNA methylation regulates the proliferation and invasion of cancer cells, but the role of m6A in cancer therapy resistance is unclear. In this review, we summarized the research progress related to the role of m6A in regulating therapy resistance in cancers. BioMed Central 2023-06-01 /pmc/articles/PMC10233906/ /pubmed/37264402 http://dx.doi.org/10.1186/s12943-023-01782-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhuang, Hengzhao
Yu, Bo
Tao, Dan
Xu, Xiaoyan
Xu, Yijun
Wang, Jian
Jiao, Yang
Wang, Lili
The role of m6A methylation in therapy resistance in cancer
title The role of m6A methylation in therapy resistance in cancer
title_full The role of m6A methylation in therapy resistance in cancer
title_fullStr The role of m6A methylation in therapy resistance in cancer
title_full_unstemmed The role of m6A methylation in therapy resistance in cancer
title_short The role of m6A methylation in therapy resistance in cancer
title_sort role of m6a methylation in therapy resistance in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233906/
https://www.ncbi.nlm.nih.gov/pubmed/37264402
http://dx.doi.org/10.1186/s12943-023-01782-2
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