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High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined (1)H-MRS study

INTRODUCTION: Unlike the effect of repetitive transcranial magnetic stimulation (rTMS) in treating neuropsychiatric diseases, little is known about how personal factors might account for the disparity of results from studies of cognition and rTMS. In this study, we investigated the effects of high-f...

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Autores principales: Li, Yanmin, Pang, Jianmin, Wang, Jing, Wang, Wei, Bo, Qianlan, Lei, Licun, Wang, Xiayue, Wang, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233929/
https://www.ncbi.nlm.nih.gov/pubmed/37275686
http://dx.doi.org/10.3389/fpsyg.2023.1144757
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author Li, Yanmin
Pang, Jianmin
Wang, Jing
Wang, Wei
Bo, Qianlan
Lei, Licun
Wang, Xiayue
Wang, Mingwei
author_facet Li, Yanmin
Pang, Jianmin
Wang, Jing
Wang, Wei
Bo, Qianlan
Lei, Licun
Wang, Xiayue
Wang, Mingwei
author_sort Li, Yanmin
collection PubMed
description INTRODUCTION: Unlike the effect of repetitive transcranial magnetic stimulation (rTMS) in treating neuropsychiatric diseases, little is known about how personal factors might account for the disparity of results from studies of cognition and rTMS. In this study, we investigated the effects of high-frequency rTMS on response inhibition control and explored the time course changes in cognitive processing and brain metabolic mechanisms after rTMS using event-related potentials (ERPs) and magnetic resonance spectroscopy ((1)H-MRS). METHODS: Participants were all right-handed and were naive to rTMS and the Go/NoGo task. Twenty-five healthy young participants underwent one 10 Hz rTMS session per day in which stimulation was applied over the left dorsolateral prefrontal cortex (DLPFC), and a homogeneous participant group of 25 individuals received a sham rTMS treatment for 1  week. A Go/NoGo task was performed, an electroencephalogram (EEG) was recorded, and (1)H-MRS was performed. RESULTS: The results revealed that there was a strong trend of decreasing commission errors of NoGo stimuli by high frequency rTMS over the left DLPFC, whereas there was no significant difference between before and after rTMS treatment with respect to these parameters in the sham rTMS group. High-frequency rTMS significantly increased the amplitude of NoGo-N2 but not Go-N2, Go-P3, or NoGo-P3. The myo-inositol /creatine complex (MI/Cr) ratio, indexing cerebral metabolism, in the left DLPFC was decreased in the rTMS treated group. DISCUSSION: This observation supports the view that high-frequency rTMS over the left DLPFC has the strong tendency of reducing commission errors behaviorally, increase the amplitude of NoGo-N2 and improve the response inhibition control of healthy young participants. The results are consistent with the excitatory properties of high frequency rTMS. We suggest that the increase in the NoGo-N2 amplitude may be related to the increased excitability of the DLPFC-anterior cingulate cortex (ACC) neural loop. Metabolic changes in the DLPFC may be a possible mechanism for the improvement of the response inhibition control of rTMS.
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spelling pubmed-102339292023-06-02 High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined (1)H-MRS study Li, Yanmin Pang, Jianmin Wang, Jing Wang, Wei Bo, Qianlan Lei, Licun Wang, Xiayue Wang, Mingwei Front Psychol Psychology INTRODUCTION: Unlike the effect of repetitive transcranial magnetic stimulation (rTMS) in treating neuropsychiatric diseases, little is known about how personal factors might account for the disparity of results from studies of cognition and rTMS. In this study, we investigated the effects of high-frequency rTMS on response inhibition control and explored the time course changes in cognitive processing and brain metabolic mechanisms after rTMS using event-related potentials (ERPs) and magnetic resonance spectroscopy ((1)H-MRS). METHODS: Participants were all right-handed and were naive to rTMS and the Go/NoGo task. Twenty-five healthy young participants underwent one 10 Hz rTMS session per day in which stimulation was applied over the left dorsolateral prefrontal cortex (DLPFC), and a homogeneous participant group of 25 individuals received a sham rTMS treatment for 1  week. A Go/NoGo task was performed, an electroencephalogram (EEG) was recorded, and (1)H-MRS was performed. RESULTS: The results revealed that there was a strong trend of decreasing commission errors of NoGo stimuli by high frequency rTMS over the left DLPFC, whereas there was no significant difference between before and after rTMS treatment with respect to these parameters in the sham rTMS group. High-frequency rTMS significantly increased the amplitude of NoGo-N2 but not Go-N2, Go-P3, or NoGo-P3. The myo-inositol /creatine complex (MI/Cr) ratio, indexing cerebral metabolism, in the left DLPFC was decreased in the rTMS treated group. DISCUSSION: This observation supports the view that high-frequency rTMS over the left DLPFC has the strong tendency of reducing commission errors behaviorally, increase the amplitude of NoGo-N2 and improve the response inhibition control of healthy young participants. The results are consistent with the excitatory properties of high frequency rTMS. We suggest that the increase in the NoGo-N2 amplitude may be related to the increased excitability of the DLPFC-anterior cingulate cortex (ACC) neural loop. Metabolic changes in the DLPFC may be a possible mechanism for the improvement of the response inhibition control of rTMS. Frontiers Media S.A. 2023-05-18 /pmc/articles/PMC10233929/ /pubmed/37275686 http://dx.doi.org/10.3389/fpsyg.2023.1144757 Text en Copyright © 2023 Li, Pang, Wang, Wang, Bo, Lei, Wang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Li, Yanmin
Pang, Jianmin
Wang, Jing
Wang, Wei
Bo, Qianlan
Lei, Licun
Wang, Xiayue
Wang, Mingwei
High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined (1)H-MRS study
title High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined (1)H-MRS study
title_full High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined (1)H-MRS study
title_fullStr High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined (1)H-MRS study
title_full_unstemmed High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined (1)H-MRS study
title_short High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined (1)H-MRS study
title_sort high-frequency rtms over the left dlpfc improves the response inhibition control of young healthy participants: an erp combined (1)h-mrs study
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233929/
https://www.ncbi.nlm.nih.gov/pubmed/37275686
http://dx.doi.org/10.3389/fpsyg.2023.1144757
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