Genome-wide CRISPR/Cas9 library screening identified ATM signaling network genes as critical drivers for resistance to ATR inhibition in soft-tissue sarcomas: synthetic lethality and therapeutic implications

Soft-tissue sarcoma (STS) are a heterogeneous group of rare tumors with different biological behavior that are fatal in more than 40% of cases, due to their metastatic evolution and inadequate treatment options. ATR inhibition already showed an activity, even if modest, in broad pre-clinical models...

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Detalles Bibliográficos
Autores principales: Spalato-Ceruso, M, Laroche-Clary, A, Perret, R, Valverde, Y, Chaire, V, Derieppe, Marie-Alix, Velasco, V, Bourdon, A, Italiano, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234020/
https://www.ncbi.nlm.nih.gov/pubmed/37259134
http://dx.doi.org/10.1186/s40164-023-00416-z

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