Cargando…

Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided?

BACKGROUND: Phacomatosis pigmentokeratotica (PPK) is a distinct and rare type of epidermal nevus syndrome characterized by coexisting nonepidermolytic organoid sebaceous nevus (SN) with one or more speckled lentiginous nevi (SLN). Atypical nevi including compound Spitz and compound dysplastic may ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jenna, Benavides, Juliana, Manwar, Rayyan, Puyana, Carolina, May, Julia, Tsoukas, Maria, Avanaki, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234170/
https://www.ncbi.nlm.nih.gov/pubmed/37113090
http://dx.doi.org/10.1111/srt.13279
_version_ 1785052426005381120
author Lee, Jenna
Benavides, Juliana
Manwar, Rayyan
Puyana, Carolina
May, Julia
Tsoukas, Maria
Avanaki, Kamran
author_facet Lee, Jenna
Benavides, Juliana
Manwar, Rayyan
Puyana, Carolina
May, Julia
Tsoukas, Maria
Avanaki, Kamran
author_sort Lee, Jenna
collection PubMed
description BACKGROUND: Phacomatosis pigmentokeratotica (PPK) is a distinct and rare type of epidermal nevus syndrome characterized by coexisting nonepidermolytic organoid sebaceous nevus (SN) with one or more speckled lentiginous nevi (SLN). Atypical nevi including compound Spitz and compound dysplastic may manifest within regions of SLN. Patients with PPK, or similar atypical nevus syndromes, may be subject to a significant lifetime number of biopsies, leading to pain, scarring, anxiety, financial burden, and decreased quality of life. The current literature includes case reports, genetics, and associated extracutaneous symptoms of PPK, but use of noninvasive imaging techniques have not been explored. We aim to investigate the value of high‐frequency ultrasound (HFUS) and optical coherence tomography (OCT) in discriminating morphological features of pigmented lesions and nevus sebaceous within one patient with PPK. MATERIALS AND METHODS: Two modalities, (1) HFUS imaging, based on acoustic properties and (2) OCT imaging, based on optical properties, were used to image a patient with PPK. Benign pigmented lesions, which may raise clinical suspicion for significant atypia, and nevus sebaceous, were selected on different areas of the body to be studied. RESULTS: Five pigmented lesions and one area of nevus sebaceous were imaged and analyzed for noninvasive features. Distinct patterns of hypoechoic features were seen on HFUS and OCT. CONCLUSION: HFUS provides a deep view of the tissue, with ability to differentiate gross structures beneath the skin. OCT provides a smaller penetration depth and a higher resolution. We have described noninvasive features of atypical nevi and nevus sebaceous on HFUS and OCT, which indicate benign etiology.
format Online
Article
Text
id pubmed-10234170
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-102341702023-08-11 Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided? Lee, Jenna Benavides, Juliana Manwar, Rayyan Puyana, Carolina May, Julia Tsoukas, Maria Avanaki, Kamran Skin Res Technol Original Articles BACKGROUND: Phacomatosis pigmentokeratotica (PPK) is a distinct and rare type of epidermal nevus syndrome characterized by coexisting nonepidermolytic organoid sebaceous nevus (SN) with one or more speckled lentiginous nevi (SLN). Atypical nevi including compound Spitz and compound dysplastic may manifest within regions of SLN. Patients with PPK, or similar atypical nevus syndromes, may be subject to a significant lifetime number of biopsies, leading to pain, scarring, anxiety, financial burden, and decreased quality of life. The current literature includes case reports, genetics, and associated extracutaneous symptoms of PPK, but use of noninvasive imaging techniques have not been explored. We aim to investigate the value of high‐frequency ultrasound (HFUS) and optical coherence tomography (OCT) in discriminating morphological features of pigmented lesions and nevus sebaceous within one patient with PPK. MATERIALS AND METHODS: Two modalities, (1) HFUS imaging, based on acoustic properties and (2) OCT imaging, based on optical properties, were used to image a patient with PPK. Benign pigmented lesions, which may raise clinical suspicion for significant atypia, and nevus sebaceous, were selected on different areas of the body to be studied. RESULTS: Five pigmented lesions and one area of nevus sebaceous were imaged and analyzed for noninvasive features. Distinct patterns of hypoechoic features were seen on HFUS and OCT. CONCLUSION: HFUS provides a deep view of the tissue, with ability to differentiate gross structures beneath the skin. OCT provides a smaller penetration depth and a higher resolution. We have described noninvasive features of atypical nevi and nevus sebaceous on HFUS and OCT, which indicate benign etiology. John Wiley and Sons Inc. 2023-04-02 /pmc/articles/PMC10234170/ /pubmed/37113090 http://dx.doi.org/10.1111/srt.13279 Text en © 2023 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Lee, Jenna
Benavides, Juliana
Manwar, Rayyan
Puyana, Carolina
May, Julia
Tsoukas, Maria
Avanaki, Kamran
Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided?
title Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided?
title_full Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided?
title_fullStr Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided?
title_full_unstemmed Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided?
title_short Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided?
title_sort noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: can biopsy of ppk patients be avoided?
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234170/
https://www.ncbi.nlm.nih.gov/pubmed/37113090
http://dx.doi.org/10.1111/srt.13279
work_keys_str_mv AT leejenna noninvasiveimagingexplorationofphacomatosispigmentokeratoticausinghighfrequencyultrasoundandopticalcoherencetomographycanbiopsyofppkpatientsbeavoided
AT benavidesjuliana noninvasiveimagingexplorationofphacomatosispigmentokeratoticausinghighfrequencyultrasoundandopticalcoherencetomographycanbiopsyofppkpatientsbeavoided
AT manwarrayyan noninvasiveimagingexplorationofphacomatosispigmentokeratoticausinghighfrequencyultrasoundandopticalcoherencetomographycanbiopsyofppkpatientsbeavoided
AT puyanacarolina noninvasiveimagingexplorationofphacomatosispigmentokeratoticausinghighfrequencyultrasoundandopticalcoherencetomographycanbiopsyofppkpatientsbeavoided
AT mayjulia noninvasiveimagingexplorationofphacomatosispigmentokeratoticausinghighfrequencyultrasoundandopticalcoherencetomographycanbiopsyofppkpatientsbeavoided
AT tsoukasmaria noninvasiveimagingexplorationofphacomatosispigmentokeratoticausinghighfrequencyultrasoundandopticalcoherencetomographycanbiopsyofppkpatientsbeavoided
AT avanakikamran noninvasiveimagingexplorationofphacomatosispigmentokeratoticausinghighfrequencyultrasoundandopticalcoherencetomographycanbiopsyofppkpatientsbeavoided