Cargando…

Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration

Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering the elderly more susceptible to dehydration. Chronically, vasopressin has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elsamad, Ghadir, Mecawi, André Souza, Pauža, Audrys G., Gillard, Benjamin, Paterson, Alex, Duque, Victor J., Šarenac, Olivera, Žigon, Nina Japundžić, Greenwood, Mingkwan, Greenwood, Michael P., Murphy, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234251/ https://www.ncbi.nlm.nih.gov/pubmed/37264028 http://dx.doi.org/10.1038/s41514-023-00108-2

Ejemplares similares

The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system
por: Greenwood, Michael P., et al.
Publicado: (2018)

Osmoregulation and the Hypothalamic Supraoptic Nucleus: From Genes to Functions
por: Mecawi, André Souza, et al.
Publicado: (2022)

Whole transcriptome organisation in the dehydrated supraoptic nucleus
por: Hindmarch, C.C.T., et al.
Publicado: (2013)

Translational and Posttranslational Dynamics in a Model Peptidergic System
por: Bárez-López, Soledad, et al.
Publicado: (2023)

Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration
por: Gillard, Benjamin T., et al.
Publicado: (2023)

Unsupervised Network Analysis of the Plastic Supraoptic Nucleus Transcriptome Predicts Caprin2 Regulatory Interactions
por: Loh, Su-Yi, et al.
Publicado: (2017)

Transcriptomic plasticity of the hypothalamic osmoregulatory control centre of the Arabian dromedary camel
por: Lin, Panjiao, et al.
Publicado: (2022)

Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review
por: Japundžić-Žigon, Nina, et al.
Publicado: (2020)

Transcriptome Analysis Reveals Downregulation of Urocortin Expression in the Hypothalamo-Neurohypophysial System of Spontaneously Hypertensive Rats
por: Martin, Andrew, et al.
Publicado: (2021)

Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation
por: Greenwood, Michael P., et al.
Publicado: (2016)

Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
por: Nguyen, Dianna H., et al.
Publicado: (2023)

Neuropeptidomics of the Supraoptic Rat Nucleus
por: Bora, Adriana, et al.
Publicado: (2008)

Autonomic mechanisms underpinning the stress response in borderline hypertensive rats
por: Šarenac, Olivera, et al.
Publicado: (2011)

The Paraventricular Nucleus of the Hypothalamus in Control of Blood Pressure and Blood Pressure Variability
por: Savić, Bojana, et al.
Publicado: (2022)

A RNA-Seq Analysis of the Rat Supraoptic Nucleus Transcriptome: Effects of Salt Loading on Gene Expression
por: Johnson, Kory R., et al.
Publicado: (2015)

Sudden death: Neurogenic causes, prediction and prevention
por: Japundžić-Žigon, Nina, et al.
Publicado: (2017)

GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition
por: Pauza, Audrys G., et al.
Publicado: (2022)

Correction: A RNA-Seq Analysis of the Rat Supraoptic Nucleus Transcriptome: Effects of Salt Loading on Gene Expression
por: Johnson, Kory R., et al.
Publicado: (2015)

Vasopressin and oxytocin expression in hypothalamic supraoptic nucleus and plasma electrolytes changes in water-deprived male Meriones libycus
por: Boumansour, Lydia, et al.
Publicado: (2021)

The importance of oxytocin neurons in the supraoptic nucleus for breastfeeding in mice
por: Hagihara, Mitsue, et al.
Publicado: (2023)

Oxytocin Cells in the Supraoptic Nucleus Receive Excitatory Synaptic Inputs from the Contralateral Supraoptic and Paraventricular Nuclei in the Lactating Rat
por: HONDA, Kazumasa, et al.
Publicado: (2013)

Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells
por: Greenwood, Mingkwan, et al.
Publicado: (2022)

Osmotic perception of GABAergic synaptic transmission in the supraoptic nucleus of rats
por: Ohbuchi, Toyoaki, et al.
Publicado: (2020)

G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis
por: Hazell, Georgina G.J., et al.
Publicado: (2012)

Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release
por: Greenwood, Michael P., et al.
Publicado: (2023)

Regulation of cAMP Responsive Element Binding Protein 3-Like 1 (Creb3l1) Expression by Orphan Nuclear Receptor Nr4a1
por: Greenwood, Michael P., et al.
Publicado: (2017)

Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation
por: Alvira-Iraizoz, Fernando, et al.
Publicado: (2021)

Electrophysiological Effects of Ghrelin in the Hypothalamic Paraventricular Nucleus Neurons
por: dos-Santos, Raoni C., et al.
Publicado: (2018)

Transcription factor Creb3l1 regulates the synthesis of prohormone convertase enzyme PC1/3 in endocrine cells
por: Greenwood, Mingkwan, et al.
Publicado: (2020)

Epigenetic Control of the Vasopressin Promoter Explains Physiological Ability to Regulate Vasopressin Transcription in Dehydration and Salt Loading States in the Rat
por: Greenwood, M. P., et al.
Publicado: (2016)

Age-dependent increase in Thy-1 protein in the rat supraoptic nucleus
por: Askvig, Jason M., et al.
Publicado: (2020)

Transcription factor CREB3L1 mediates cAMP and glucocorticoid regulation of arginine vasopressin gene transcription in the rat hypothalamus
por: Greenwood, Mingkwan, et al.
Publicado: (2015)

Effects of nitric oxide on magnocellular neurons of the supraoptic nucleus involve multiple mechanisms
por: da Silva, M.P., et al.
Publicado: (2014)

Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity in Rat Supraoptic Nucleus
por: Wang, Ping, et al.
Publicado: (2019)

Microdissection of the supraoptic nucleus and posterior pituitary gland from fresh unfixed tissue
por: Thompson, Derick, et al.
Publicado: (2023)

The Use of Protein-DNA, Chromatin Immunoprecipitation, and Transcriptome Arrays to Describe Transcriptional Circuits in the Dehydrated Male Rat Hypothalamus
por: Qiu, Jing, et al.
Publicado: (2014)

Intracisternally Injected L-Proline Activates Hypothalamic Supraoptic, but Not Paraventricular, Vasopressin-Expressing Neurons in Conscious Rats
por: Takemoto, Yumi
Publicado: (2011)

Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity
por: Thompson, Derick, et al.
Publicado: (2023)

Vasopressin and Oxytocin in Control of the Cardiovascular System
por: Japundžić-Žigon, Nina
Publicado: (2013)

An Update on Blood Pressure Short-Term Variability
por: Japundžić-Žigon, Nina
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_crb2i18mnrqjh0q0npmv18l3av