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Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses
Increased human activities around the globe and the rapid development of once rural regions have increased the probability of contact between humans and wild animals. A majority of bunyaviruses are of zoonotic origin, and outbreaks may result in the substantial loss of lives, economy contraction, an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234439/ https://www.ncbi.nlm.nih.gov/pubmed/37274315 http://dx.doi.org/10.3389/fcimb.2023.1174030 |
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author | Chen, Tong Ding, Zhe Lan, Jiaming Wong, Gary |
author_facet | Chen, Tong Ding, Zhe Lan, Jiaming Wong, Gary |
author_sort | Chen, Tong |
collection | PubMed |
description | Increased human activities around the globe and the rapid development of once rural regions have increased the probability of contact between humans and wild animals. A majority of bunyaviruses are of zoonotic origin, and outbreaks may result in the substantial loss of lives, economy contraction, and social instability. Many bunyaviruses require manipulation in the highest levels of biocontainment, such as Biosafety Level 4 (BSL-4) laboratories, and the scarcity of this resource has limited the development speed of vaccines for these pathogens. Meanwhile, new technologies have been created, and used to innovate vaccines, like the mRNA vaccine platform and bioinformatics-based antigen design. Here, we summarize current vaccine developments for three different bunyaviruses requiring work in the highest levels of biocontainment: Crimean-Congo Hemorrhagic Fever Virus (CCHFV), Rift Valley Fever Virus (RVFV), and Hantaan virus (HTNV), and provide perspectives and potential future directions that can be further explored to advance specific vaccines for humans and livestock. |
format | Online Article Text |
id | pubmed-10234439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102344392023-06-02 Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses Chen, Tong Ding, Zhe Lan, Jiaming Wong, Gary Front Cell Infect Microbiol Cellular and Infection Microbiology Increased human activities around the globe and the rapid development of once rural regions have increased the probability of contact between humans and wild animals. A majority of bunyaviruses are of zoonotic origin, and outbreaks may result in the substantial loss of lives, economy contraction, and social instability. Many bunyaviruses require manipulation in the highest levels of biocontainment, such as Biosafety Level 4 (BSL-4) laboratories, and the scarcity of this resource has limited the development speed of vaccines for these pathogens. Meanwhile, new technologies have been created, and used to innovate vaccines, like the mRNA vaccine platform and bioinformatics-based antigen design. Here, we summarize current vaccine developments for three different bunyaviruses requiring work in the highest levels of biocontainment: Crimean-Congo Hemorrhagic Fever Virus (CCHFV), Rift Valley Fever Virus (RVFV), and Hantaan virus (HTNV), and provide perspectives and potential future directions that can be further explored to advance specific vaccines for humans and livestock. Frontiers Media S.A. 2023-05-18 /pmc/articles/PMC10234439/ /pubmed/37274315 http://dx.doi.org/10.3389/fcimb.2023.1174030 Text en Copyright © 2023 Chen, Ding, Lan and Wong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Chen, Tong Ding, Zhe Lan, Jiaming Wong, Gary Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses |
title | Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses |
title_full | Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses |
title_fullStr | Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses |
title_full_unstemmed | Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses |
title_short | Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses |
title_sort | advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234439/ https://www.ncbi.nlm.nih.gov/pubmed/37274315 http://dx.doi.org/10.3389/fcimb.2023.1174030 |
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