Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma

INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck cancer. Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC. OBJECTIVE: Analyze the immunohistochemical expression...

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Detalles Bibliográficos
Autores principales: Escobar, Enrico, Gómez-Valenzuela, Fernán, Peñafiel, Cristian, Hormazábal-Hevia, Alondra, Herrera-Fuentes, Constanza, Mori-Aliaga, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedad Española de Anatomía Patológica. Published by Elsevier España, S.L.U. 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234467/
https://www.ncbi.nlm.nih.gov/pubmed/37419553
http://dx.doi.org/10.1016/j.patol.2023.02.005
Descripción
Sumario:INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck cancer. Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC. OBJECTIVE: Analyze the immunohistochemical expression of COX-2, Ki-67 (cell proliferation), Bcl-2/Bax (apoptosis), VEGF, and CD105 (angiogenesis) according to histological grades of OSCC. MATERIAL AND METHODS: The immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF, and CD105 of 58 cases of OSCC was analyzed. 13 cases of oral mucosa (OM) were analyzed as controls. RESULTS: COX-2, VEGF, CD105, and Ki-67 were higher in OSCC than in OM, particularly in poorly differentiated OSCC (p < 0.05). Bax expression was lower in poorly differentiated OSCC (p < 0.001). The Bcl-2/Bax ratio was higher in OSCC compared to MO (p < 0.05). CONCLUSION: There are immunohistochemical differences according to histological grades of OSCC, which could influence clinical behavior.

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