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Validation of a genome-wide polygenic score in improving fracture risk assessment beyond the FRAX tool in the Women’s Health Initiative study
BACKGROUND: Previous study has established two polygenic scores (PGSs) related to femoral neck bone mineral density (BMD) (PGS_FNBMD(ldpred)) and total body BMD (PGS_TBBMD(ldpred)) that are associated with fracture risk. However, these findings have not yet been externally validated in an independen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234531/ https://www.ncbi.nlm.nih.gov/pubmed/37262069 http://dx.doi.org/10.1371/journal.pone.0286689 |