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Validation of a genome-wide polygenic score in improving fracture risk assessment beyond the FRAX tool in the Women’s Health Initiative study

BACKGROUND: Previous study has established two polygenic scores (PGSs) related to femoral neck bone mineral density (BMD) (PGS_FNBMD(ldpred)) and total body BMD (PGS_TBBMD(ldpred)) that are associated with fracture risk. However, these findings have not yet been externally validated in an independen...

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Detalles Bibliográficos
Autores principales: Xiao, Xiangxue, Wu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234531/
https://www.ncbi.nlm.nih.gov/pubmed/37262069
http://dx.doi.org/10.1371/journal.pone.0286689

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