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Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth
In most animals, pluripotency is irreversibly lost post gastrulation. By this stage, all embryonic cells have already committed either to one of the somatic lineages (ectoderm, endoderm, or mesoderm) or to the germline. The lack of pluripotent cells in adult life may be linked to organismal aging. C...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234598/ https://www.ncbi.nlm.nih.gov/pubmed/37028430 http://dx.doi.org/10.1016/j.cub.2023.03.039 |
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author | Varley, Áine Horkan, Helen R. McMahon, Emma T. Krasovec, Gabriel Frank, Uri |
author_facet | Varley, Áine Horkan, Helen R. McMahon, Emma T. Krasovec, Gabriel Frank, Uri |
author_sort | Varley, Áine |
collection | PubMed |
description | In most animals, pluripotency is irreversibly lost post gastrulation. By this stage, all embryonic cells have already committed either to one of the somatic lineages (ectoderm, endoderm, or mesoderm) or to the germline. The lack of pluripotent cells in adult life may be linked to organismal aging. Cnidarians (corals and jellyfish) are an early branch of animals that do not succumb to age, but the developmental potential of their adult stem cells remains unclear. Here, we show that adult stem cells in the cnidarian Hydractinia symbiolongicarpus (known as i-cells) are pluripotent. We transplanted single i-cells from transgenic fluorescent donors to wild-type recipients and followed them in vivo in the translucent animals. Single engrafted i-cells self-renewed and contributed to all somatic lineages and gamete production, co-existing with and eventually displacing the allogeneic recipient’s cells. Hence, a fully functional, sexually competent individual can derive from a single adult i-cell. Pluripotent i-cells enable regenerative, plant-like clonal growth in these animals. |
format | Online Article Text |
id | pubmed-10234598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-102345982023-06-02 Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth Varley, Áine Horkan, Helen R. McMahon, Emma T. Krasovec, Gabriel Frank, Uri Curr Biol Article In most animals, pluripotency is irreversibly lost post gastrulation. By this stage, all embryonic cells have already committed either to one of the somatic lineages (ectoderm, endoderm, or mesoderm) or to the germline. The lack of pluripotent cells in adult life may be linked to organismal aging. Cnidarians (corals and jellyfish) are an early branch of animals that do not succumb to age, but the developmental potential of their adult stem cells remains unclear. Here, we show that adult stem cells in the cnidarian Hydractinia symbiolongicarpus (known as i-cells) are pluripotent. We transplanted single i-cells from transgenic fluorescent donors to wild-type recipients and followed them in vivo in the translucent animals. Single engrafted i-cells self-renewed and contributed to all somatic lineages and gamete production, co-existing with and eventually displacing the allogeneic recipient’s cells. Hence, a fully functional, sexually competent individual can derive from a single adult i-cell. Pluripotent i-cells enable regenerative, plant-like clonal growth in these animals. Cell Press 2023-05-22 /pmc/articles/PMC10234598/ /pubmed/37028430 http://dx.doi.org/10.1016/j.cub.2023.03.039 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Varley, Áine Horkan, Helen R. McMahon, Emma T. Krasovec, Gabriel Frank, Uri Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth |
title | Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth |
title_full | Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth |
title_fullStr | Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth |
title_full_unstemmed | Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth |
title_short | Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth |
title_sort | pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234598/ https://www.ncbi.nlm.nih.gov/pubmed/37028430 http://dx.doi.org/10.1016/j.cub.2023.03.039 |
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