Cargando…

Limitations of principal components in quantitative genetic association models for human studies

Principal Component Analysis (PCA) and the Linear Mixed-effects Model (LMM), sometimes in combination, are the most common genetic association models. Previous PCA-LMM comparisons give mixed results, unclear guidance, and have several limitations, including not varying the number of principal compon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yao, Yiqi, Ochoa, Alejandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234632/ https://www.ncbi.nlm.nih.gov/pubmed/37140344 http://dx.doi.org/10.7554/eLife.79238

Ejemplares similares

Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers
por: Schmid, Annina B, et al.
Publicado: (2019)

Correcting Principal Component Maps for Effects of Spatial Autocorrelation in Population Genetic Data
por: Frichot, Eric, et al.
Publicado: (2012)

Principal component analysis reveals the 1000 Genomes Project does not sufficiently cover the human genetic diversity in Asia
por: Lu, Dongsheng, et al.
Publicado: (2013)

Incorporating Prior Knowledge of Principal Components in Genomic Prediction
por: Hosseini-Vardanjani, Sayed M., et al.
Publicado: (2018)

Self-limiting population genetic control with sex-linked genome editors
por: Burt, Austin, et al.
Publicado: (2018)

Detecting Genotype-Population Interaction Effects by Ancestry Principal Components
por: Yu, Chenglong, et al.
Publicado: (2020)

Quantitative relationship between functionally active telomerase and major telomerase components (hTERT and hTR) in acute leukaemia cells
por: Ohyashiki, J H, et al.
Publicado: (2005)

Quantitative genetic-by-soil microbiome interactions in a perennial grass affect functional traits
por: Khasanova, Albina, et al.
Publicado: (2023)

ITRPCA: a new model for computational drug repositioning based on improved tensor robust principal component analysis
por: Yang, Mengyun, et al.
Publicado: (2023)

Colonization of a commercial broiler line by Campylobacter is under limited genetic control and does not significantly impair performance or intestinal health
por: Bailey, Richard A, et al.
Publicado: (2018)

Anticipated health behaviour changes and perceived control in response to disclosure of genetic risk of breast and ovarian cancer: a quantitative survey study among women in the UK
por: Meisel, Susanne F, et al.
Publicado: (2017)

The BOADICEA model of genetic susceptibility to breast and ovarian cancer
por: Antoniou, A C, et al.
Publicado: (2004)

Genetic regulation of MUC1 alternative splicing in human tissues
por: Ng, W, et al.
Publicado: (2008)

Novel genetic loci affecting facial shape variation in humans
por: Xiong, Ziyi, et al.
Publicado: (2019)

Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study
por: Lombard, Zané, et al.
Publicado: (2012)

Restriction site-associated DNA sequencing for SNP discovery and high-density genetic map construction in southern catfish (Silurus meridionalis)
por: Xie, Mimi, et al.
Publicado: (2018)

Genetic architecture of natural variation of cardiac performance from flies to humans
por: Saha, Saswati, et al.
Publicado: (2022)

Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia
por: Hou, H-A, et al.
Publicado: (2011)

A Principal Component Informed Approach to Address Polygenic Risk Score Transferability Across European Cohorts
por: Pärna, Katri, et al.
Publicado: (2022)

The missing link between genetic association and regulatory function
por: Connally, Noah J, et al.
Publicado: (2022)

Biometric variability of goat populations revealed by means of principal component analysis
por: Pires, Luanna Chácara, et al.
Publicado: (2012)

The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
por: Antoniou, A C, et al.
Publicado: (2008)

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis
por: Nandakumar, Satish K, et al.
Publicado: (2019)

Human genetic analyses of organelles highlight the nucleus in age-related trait heritability
por: Gupta, Rahul, et al.
Publicado: (2021)

Associations of genetic and infectious risk factors with coronary heart disease
por: Hodel, Flavia, et al.
Publicado: (2023)

Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium
por: Pearce, C L, et al.
Publicado: (2009)

Thirst interneurons that promote water seeking and limit feeding behavior in Drosophila
por: Landayan, Dan, et al.
Publicado: (2021)

TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations
por: Labussière, M, et al.
Publicado: (2014)

Rare variants contribute disproportionately to quantitative trait variation in yeast
por: Bloom, Joshua S, et al.
Publicado: (2019)

Body mass index and adipose distribution have opposing genetic impacts on human blood traits
por: Thom, Christopher S, et al.
Publicado: (2022)

Development and validation of a brief screening instrument for psychosocial risk associated with genetic testing: a pan-Canadian cohort study
por: Esplen, Mary Jane, et al.
Publicado: (2013)

Common genetic variants in the 9p21 region and their associations with multiple tumours
por: Gu, F, et al.
Publicado: (2013)

Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component
por: Alonso, M Henar, et al.
Publicado: (2017)

Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia
por: Schubert, Stephanie A, et al.
Publicado: (2017)

Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes
por: de Wet, Timothy J, et al.
Publicado: (2020)

Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster
por: Lyman, Richard F., et al.
Publicado: (2023)

Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts
por: Parker, Margaret M, et al.
Publicado: (2019)

Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function
por: Reay, William R, et al.
Publicado: (2021)

Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression
por: Upadhyay, Ambuj, et al.
Publicado: (2022)

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
por: Smith, Clare M, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4iq9vnjf6pnd9mavo12hsoifs5