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Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis

Many studies report Liver kinase B1 (LKB1) plays a critical role in gastric cancer (GC). However, the relationship between LKB1 and the clinicopathological parameters of GC patients remains controversial. This meta-analysis aimed to investigate the above question and re-evaluate the prognostic signi...

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Autores principales: Tan, Guojiang, Liu, Baiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235053/
https://www.ncbi.nlm.nih.gov/pubmed/37264076
http://dx.doi.org/10.1038/s41598-023-36239-5
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author Tan, Guojiang
Liu, Baiying
author_facet Tan, Guojiang
Liu, Baiying
author_sort Tan, Guojiang
collection PubMed
description Many studies report Liver kinase B1 (LKB1) plays a critical role in gastric cancer (GC). However, the relationship between LKB1 and the clinicopathological parameters of GC patients remains controversial. This meta-analysis aimed to investigate the above question and re-evaluate the prognostic significance of LKB1 in GC patients. We searched PubMed, Web of Science, Cochrane Library, Google Scholar, CNKI, and Wan Fang to identify relevant studies published before April 20, 2023. After careful screening, 11 studies involving 1767 patients were included. We found that LKB1 expression was significantly related to tumor size (OR 0.515; 95% CI 0.316–0.839; P < 0.01), differentiation (OR 0.643; 95% CI 0.521–0.794; P < 0.001), depth of invasion (OR 0.397; 95% CI 0.319–0.494; P < 0.001), lymph node metastasis (OR 0.487; 95% CI 0.397–0.598; P = 0.01), and TNM stage (OR 0.362; 95% CI 0.293–0.447; P = 0.006). However, LKB1 was unrelated to gender and age (P > 0.05). Moreover, low LKB1 expression was significant correlate with overall survival (OS) (HR = 1.59; 95% CI 1.29–1.96; P < 0.001). In conclusion, LKB1 expression is related to tumor size, differentiation, depth of invasion, lymph node metastasis, and TNM stage, and low LKB1 expression can predict a poor prognosis. LKB1 is a potentially valuable prognosis signature and therapeutic target in GC patients.
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spelling pubmed-102350532023-06-03 Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis Tan, Guojiang Liu, Baiying Sci Rep Article Many studies report Liver kinase B1 (LKB1) plays a critical role in gastric cancer (GC). However, the relationship between LKB1 and the clinicopathological parameters of GC patients remains controversial. This meta-analysis aimed to investigate the above question and re-evaluate the prognostic significance of LKB1 in GC patients. We searched PubMed, Web of Science, Cochrane Library, Google Scholar, CNKI, and Wan Fang to identify relevant studies published before April 20, 2023. After careful screening, 11 studies involving 1767 patients were included. We found that LKB1 expression was significantly related to tumor size (OR 0.515; 95% CI 0.316–0.839; P < 0.01), differentiation (OR 0.643; 95% CI 0.521–0.794; P < 0.001), depth of invasion (OR 0.397; 95% CI 0.319–0.494; P < 0.001), lymph node metastasis (OR 0.487; 95% CI 0.397–0.598; P = 0.01), and TNM stage (OR 0.362; 95% CI 0.293–0.447; P = 0.006). However, LKB1 was unrelated to gender and age (P > 0.05). Moreover, low LKB1 expression was significant correlate with overall survival (OS) (HR = 1.59; 95% CI 1.29–1.96; P < 0.001). In conclusion, LKB1 expression is related to tumor size, differentiation, depth of invasion, lymph node metastasis, and TNM stage, and low LKB1 expression can predict a poor prognosis. LKB1 is a potentially valuable prognosis signature and therapeutic target in GC patients. Nature Publishing Group UK 2023-06-01 /pmc/articles/PMC10235053/ /pubmed/37264076 http://dx.doi.org/10.1038/s41598-023-36239-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Tan, Guojiang
Liu, Baiying
Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis
title Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis
title_full Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis
title_fullStr Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis
title_full_unstemmed Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis
title_short Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis
title_sort clinicopathological and prognostic significance of lkb1 expression in gastric cancer: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235053/
https://www.ncbi.nlm.nih.gov/pubmed/37264076
http://dx.doi.org/10.1038/s41598-023-36239-5
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