Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice

Concentrative nucleoside transporters (CNTs) are active nucleoside influx systems, but their in vivo roles are poorly defined. By generating CNT1 knockout (KO) mice, here we identify a role of CNT1 in the renal reabsorption of nucleosides. Deletion of CNT1 in mice increases the urinary excretion of...

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Detalles Bibliográficos
Autores principales: Persaud, Avinash K., Bernier, Matthew C., Massey, Michael A., Agrawal, Shipra, Kaur, Tejinder, Nayak, Debasis, Xie, Zhiliang, Weadick, Brenna, Raj, Ruchika, Hill, Kasey, Abbott, Nicole, Joshi, Arnav, Anabtawi, Nadeen, Bryant, Claire, Somogyi, Arpad, Cruz-Monserrate, Zobeida, Amari, Foued, Coppola, Vincenzo, Sparreboom, Alex, Baker, Sharyn D., Unadkat, Jashvant D., Phelps, Mitch A., Govindarajan, Rajgopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235067/
https://www.ncbi.nlm.nih.gov/pubmed/37264059
http://dx.doi.org/10.1038/s41467-023-38789-8

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