Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickens

Intravenous immunoglobulin (IVIG) is a plasma-derived polyclonal IgG used for treatment of autoimmune diseases. Studies show that α-2,6 sialylation of the Fc improves anti-inflammatory activity. Also, afucosylation of the Fc efficiently blocks FcγRIIIA by increasing monovalent affinity to this recep...

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Detalles Bibliográficos
Autores principales: Park, Jin Se, Choi, Hee Jung, Jung, Kyung Min, Lee, Kyung Youn, Shim, Ji Hyeon, Park, Kyung Je, Kim, Young Min, Han, Jae Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235082/
https://www.ncbi.nlm.nih.gov/pubmed/37264071
http://dx.doi.org/10.1038/s42003-023-04937-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235082/
https://www.ncbi.nlm.nih.gov/pubmed/37264071
http://dx.doi.org/10.1038/s42003-023-04937-5

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