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Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickens

Intravenous immunoglobulin (IVIG) is a plasma-derived polyclonal IgG used for treatment of autoimmune diseases. Studies show that α-2,6 sialylation of the Fc improves anti-inflammatory activity. Also, afucosylation of the Fc efficiently blocks FcγRIIIA by increasing monovalent affinity to this recep...

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Detalles Bibliográficos
Autores principales:	Park, Jin Se, Choi, Hee Jung, Jung, Kyung Min, Lee, Kyung Youn, Shim, Ji Hyeon, Park, Kyung Je, Kim, Young Min, Han, Jae Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235082/ https://www.ncbi.nlm.nih.gov/pubmed/37264071 http://dx.doi.org/10.1038/s42003-023-04937-5

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