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Machine learning for predicting survival of colorectal cancer patients

Colorectal cancer is one of the most incident types of cancer in the world, with almost 2 million new cases annually. In Brazil, the scenery is the same, around 41 thousand new cases were estimated in the last 3 years. This increase in cases further intensifies the interest and importance of studies...

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Autores principales: Buk Cardoso, Lucas, Cunha Parro, Vanderlei, Verzinhasse Peres, Stela, Curado, Maria Paula, Fernandes, Gisele Aparecida, Wünsch Filho, Victor, Natasha Toporcov, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235087/
https://www.ncbi.nlm.nih.gov/pubmed/37264045
http://dx.doi.org/10.1038/s41598-023-35649-9
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author Buk Cardoso, Lucas
Cunha Parro, Vanderlei
Verzinhasse Peres, Stela
Curado, Maria Paula
Fernandes, Gisele Aparecida
Wünsch Filho, Victor
Natasha Toporcov, Tatiana
author_facet Buk Cardoso, Lucas
Cunha Parro, Vanderlei
Verzinhasse Peres, Stela
Curado, Maria Paula
Fernandes, Gisele Aparecida
Wünsch Filho, Victor
Natasha Toporcov, Tatiana
author_sort Buk Cardoso, Lucas
collection PubMed
description Colorectal cancer is one of the most incident types of cancer in the world, with almost 2 million new cases annually. In Brazil, the scenery is the same, around 41 thousand new cases were estimated in the last 3 years. This increase in cases further intensifies the interest and importance of studies related to the topic, especially using new approaches. The use of machine learning algorithms for cancer studies has grown in recent years, and they can provide important information to medicine, in addition to making predictions based on the data. In this study, five different classifications were performed, considering patients’ survival. Data were extracted from Hospital Based Cancer Registries of São Paulo, which is coordinated by Fundação Oncocentro de São Paulo, containing patients with colorectal cancer from São Paulo state, Brazil, treated between 2000 and 2021. The machine learning models used provided us the predictions and the most important features for each one of the algorithms of the studies. Using part of the dataset to validate our models, the results of the predictors were around 77% of accuracy, with AUC close to 0.86, and the most important column was the clinical staging in all of them.
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spelling pubmed-102350872023-06-03 Machine learning for predicting survival of colorectal cancer patients Buk Cardoso, Lucas Cunha Parro, Vanderlei Verzinhasse Peres, Stela Curado, Maria Paula Fernandes, Gisele Aparecida Wünsch Filho, Victor Natasha Toporcov, Tatiana Sci Rep Article Colorectal cancer is one of the most incident types of cancer in the world, with almost 2 million new cases annually. In Brazil, the scenery is the same, around 41 thousand new cases were estimated in the last 3 years. This increase in cases further intensifies the interest and importance of studies related to the topic, especially using new approaches. The use of machine learning algorithms for cancer studies has grown in recent years, and they can provide important information to medicine, in addition to making predictions based on the data. In this study, five different classifications were performed, considering patients’ survival. Data were extracted from Hospital Based Cancer Registries of São Paulo, which is coordinated by Fundação Oncocentro de São Paulo, containing patients with colorectal cancer from São Paulo state, Brazil, treated between 2000 and 2021. The machine learning models used provided us the predictions and the most important features for each one of the algorithms of the studies. Using part of the dataset to validate our models, the results of the predictors were around 77% of accuracy, with AUC close to 0.86, and the most important column was the clinical staging in all of them. Nature Publishing Group UK 2023-06-01 /pmc/articles/PMC10235087/ /pubmed/37264045 http://dx.doi.org/10.1038/s41598-023-35649-9 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Buk Cardoso, Lucas
Cunha Parro, Vanderlei
Verzinhasse Peres, Stela
Curado, Maria Paula
Fernandes, Gisele Aparecida
Wünsch Filho, Victor
Natasha Toporcov, Tatiana
Machine learning for predicting survival of colorectal cancer patients
title Machine learning for predicting survival of colorectal cancer patients
title_full Machine learning for predicting survival of colorectal cancer patients
title_fullStr Machine learning for predicting survival of colorectal cancer patients
title_full_unstemmed Machine learning for predicting survival of colorectal cancer patients
title_short Machine learning for predicting survival of colorectal cancer patients
title_sort machine learning for predicting survival of colorectal cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235087/
https://www.ncbi.nlm.nih.gov/pubmed/37264045
http://dx.doi.org/10.1038/s41598-023-35649-9
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