Cargando…

Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer

The tumor immune composition influences prognosis and treatment sensitivity in lung cancer. The presence of effective adaptive immune responses is associated with increased clinical benefit after immune checkpoint blockers. Conversely, immunotherapy resistance can occur as a consequence of local T-c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barrera, Cristian, Corredor, Germán, Viswanathan, Vidya Sankar, Ding, Ruiwen, Toro, Paula, Fu, Pingfu, Buzzy, Christina, Lu, Cheng, Velu, Priya, Zens, Philipp, Berezowska, Sabina, Belete, Merzu, Balli, David, Chang, Han, Baxi, Vipul, Syrigos, Konstantinos, Rimm, David L., Velcheti, Vamsidhar, Schalper, Kurt, Romero, Eduardo, Madabhushi, Anant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235089/ https://www.ncbi.nlm.nih.gov/pubmed/37264091 http://dx.doi.org/10.1038/s41698-023-00403-x

Ejemplares similares

Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome
por: Ding, Ruiwen, et al.
Publicado: (2022)

A tumor vasculature–based imaging biomarker for predicting response and survival in patients with lung cancer treated with checkpoint inhibitors
por: Alilou, Mehdi, et al.
Publicado: (2022)

Prediction of recurrence in early stage non-small cell lung cancer using computer extracted nuclear features from digital H&E images
por: Wang, Xiangxue, et al.
Publicado: (2017)

Spatial interplay patterns of cancer nuclei and tumor-infiltrating lymphocytes (TILs) predict clinical benefit for immune checkpoint inhibitors
por: Wang, Xiangxue, et al.
Publicado: (2022)

A prognostic model for overall survival of patients with early-stage non-small cell lung cancer: a multicentre, retrospective study
por: Lu, Cheng, et al.
Publicado: (2020)

The state of the art for artificial intelligence in lung digital pathology
por: Viswanathan, Vidya Sankar, et al.
Publicado: (2022)

Machine Learning to Predict Risk of Relapse Using Cytologic Image Markers in Patients With Acute Myeloid Leukemia Posthematopoietic Cell Transplantation
por: Arabyarmohammadi, Sara, et al.
Publicado: (2022)

Response to: Correspondence on 'Novel imaging biomarkers predict outcomes in stage III unresectable non-small cell lung cancer treated with chemoradiation and durvalumab' by Zheng et al
por: Viswanathan, Vidya Sankar, et al.
Publicado: (2022)

A prognostic and predictive computational pathology image signature for added benefit of adjuvant chemotherapy in early stage non-small-cell lung cancer
por: Wang, Xiangxue, et al.
Publicado: (2021)

Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer
por: Carvajal-Hausdorf, Daniel E., et al.
Publicado: (2017)

Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer
por: Lopez de Rodas, Miguel, et al.
Publicado: (2022)

Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)
por: Carvajal-Hausdorf, Daniel, et al.
Publicado: (2019)

High SOX2 Levels Predict Better Outcome in Non-Small Cell Lung Carcinomas
por: Velcheti, Vamsidhar, et al.
Publicado: (2013)

Novel Non-Invasive Radiomic Signature on CT Scans Predicts Response to Platinum-Based Chemotherapy and Is Prognostic of Overall Survival in Small Cell Lung Cancer
por: Jain, Prantesh, et al.
Publicado: (2021)

Clinical significance of PD-L1 protein expression on tumor-associated macrophages in lung cancer
por: Schalper, Kurt Alex, et al.
Publicado: (2015)

CT radiomic signature predicts survival and chemotherapy benefit in stage I and II HPV-associated oropharyngeal carcinoma
por: Song, Bolin, et al.
Publicado: (2023)

Novel, non-invasive imaging approach to identify patients with advanced non-small cell lung cancer at risk of hyperprogressive disease with immune checkpoint blockade
por: Vaidya, Pranjal, et al.
Publicado: (2020)

Computational image features of immune architecture is associated with clinical benefit and survival in gynecological cancers across treatment modalities
por: Azarianpour, Sepideh, et al.
Publicado: (2022)

A Novel Nodule Edge Sharpness Radiomic Biomarker Improves Performance of Lung-RADS for Distinguishing Adenocarcinomas from Granulomas on Non-Contrast CT Scans
por: Alilou, Mehdi, et al.
Publicado: (2021)

Novel imaging biomarkers predict outcomes in stage III unresectable non-small cell lung cancer treated with chemoradiation and durvalumab
por: Jazieh, Khalid, et al.
Publicado: (2022)

Computational pathology improves risk stratification of a multi-gene assay for early stage ER+ breast cancer
por: Chen, Yuli, et al.
Publicado: (2023)

An Imaging Biomarker of Tumor-Infiltrating Lymphocytes to Risk-Stratify Patients With HPV-Associated Oropharyngeal Cancer
por: Corredor, Germán, et al.
Publicado: (2021)

A Case of a Patient with Idiopathic Pulmonary Fibrosis with Lung Squamous Cell Carcinoma Treated with Nivolumab
por: Khunger, Monica, et al.
Publicado: (2017)

Quantitative vessel tortuosity: A potential CT imaging biomarker for distinguishing lung granulomas from adenocarcinomas
por: Alilou, Mehdi, et al.
Publicado: (2018)

Author Correction: Quantitative vessel tortuosity: A potential CT imaging biomarker for distinguishing lung granulomas from adenocarcinomas
por: Alilou, Mehdi, et al.
Publicado: (2019)

Novel pharmacologic approach to enhance the epigenetic and immune priming effect of decitabine in patients with advanced non-small cell lung cancer
por: Velcheti, Vamsidhar, et al.
Publicado: (2015)

Novel radiomic analysis on bi-parametric MRI for characterizing differences between MR non-visible and visible clinically significant prostate cancer
por: Li, Lin, et al.
Publicado: (2023)

Management of patients with advanced non-small cell lung cancer: role of gefitinib
por: Velcheti, Vamsidhar, et al.
Publicado: (2010)

Role of immune-checkpoint inhibitors in lung cancer
por: Jain, Prantesh, et al.
Publicado: (2018)

Dabrafenib in combination with trametinib in the treatment of patients with BRAF V600-positive advanced or metastatic non-small cell lung cancer: clinical evidence and experience
por: Khunger, Arjun, et al.
Publicado: (2018)

Combined Radiomic and Visual Assessment for Improved Detection of Lung Adenocarcinoma Invasiveness on Computed Tomography Scans: A Multi-Institutional Study
por: Vaidya, Pranjal, et al.
Publicado: (2022)

Computer‐extracted features of nuclear morphology in hematoxylin and eosin images distinguish stage II and IV colon tumors
por: Kumar, Neeraj, et al.
Publicado: (2022)

Real-world outcomes of first-line pembrolizumab plus pemetrexed-carboplatin for metastatic nonsquamous NSCLC at US oncology practices
por: Velcheti, Vamsidhar, et al.
Publicado: (2021)

Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer
por: McColl, Karen, et al.
Publicado: (2017)

Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findings
por: Midya, Abhishek, et al.
Publicado: (2023)

Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy
por: Biswas, Sudipta, et al.
Publicado: (2023)

Focal lung infiltrate complicating PD-1 inhibitor use: A new pattern of drug-associated lung toxicity?
por: Sehgal, Sameep, et al.
Publicado: (2016)

Machine learning derived ECG risk score improves cardiovascular risk assessment in conjunction with coronary artery calcium scoring
por: Siva Kumar, Shruti, et al.
Publicado: (2022)

A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI
por: Li, Lin, et al.
Publicado: (2020)

Quantitative Measurement of Cancer Tissue Biomarkers in the Lab and in the Clinic
por: Carvajal-Hausdorf, Daniel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rmerjl730hk4lsgeasfd5brvoh