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Esophageal microflora in esophageal diseases

With the development of endoscopic technology, an increasing number of patients with esophageal disease are being diagnosed, although the underlying pathogenesis of many esophageal diseases remains unclear. In recent years, a large number of studies have demonstrated that the occurrence and developm...

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Autores principales: Zou, Qian, Feng, Lijuan, Cai, Xunchao, Qian, Yun, Xu, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235470/
https://www.ncbi.nlm.nih.gov/pubmed/37274313
http://dx.doi.org/10.3389/fcimb.2023.1145791
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author Zou, Qian
Feng, Lijuan
Cai, Xunchao
Qian, Yun
Xu, Long
author_facet Zou, Qian
Feng, Lijuan
Cai, Xunchao
Qian, Yun
Xu, Long
author_sort Zou, Qian
collection PubMed
description With the development of endoscopic technology, an increasing number of patients with esophageal disease are being diagnosed, although the underlying pathogenesis of many esophageal diseases remains unclear. In recent years, a large number of studies have demonstrated that the occurrence and development of various intestinal diseases were related to intestinal flora. As a result, researchers have shifted their focus towards investigating esophageal flora to better understand the pathogenesis, early diagnosis, and treatment of esophageal diseases. This paper reviewed the normal esophageal flora and the changes of esophageal flora under different esophageal disease states. It was observed that there are distinct differences in the composition of esophageal microflora among Gastroesophageal Reflux, Barrett’s esophagus, eosinophilic esophagitis and normal esophagus. The normal esophageal flora was dominated by gram-positive bacteria, particularly Streptococcus, while the esophageal flora under esophagitis was dominated by gram-negative bacteria. Furthermore, the diversity of esophageal flora is significantly decreased in patients with esophageal cancer. Several potential microbial biomarkers for esophageal cancer have been identified, among which Fusobacterium nucleatum showed a close association with esophageal squamous cell carcinoma’s pathological stage and clinical stage.
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spelling pubmed-102354702023-06-03 Esophageal microflora in esophageal diseases Zou, Qian Feng, Lijuan Cai, Xunchao Qian, Yun Xu, Long Front Cell Infect Microbiol Cellular and Infection Microbiology With the development of endoscopic technology, an increasing number of patients with esophageal disease are being diagnosed, although the underlying pathogenesis of many esophageal diseases remains unclear. In recent years, a large number of studies have demonstrated that the occurrence and development of various intestinal diseases were related to intestinal flora. As a result, researchers have shifted their focus towards investigating esophageal flora to better understand the pathogenesis, early diagnosis, and treatment of esophageal diseases. This paper reviewed the normal esophageal flora and the changes of esophageal flora under different esophageal disease states. It was observed that there are distinct differences in the composition of esophageal microflora among Gastroesophageal Reflux, Barrett’s esophagus, eosinophilic esophagitis and normal esophagus. The normal esophageal flora was dominated by gram-positive bacteria, particularly Streptococcus, while the esophageal flora under esophagitis was dominated by gram-negative bacteria. Furthermore, the diversity of esophageal flora is significantly decreased in patients with esophageal cancer. Several potential microbial biomarkers for esophageal cancer have been identified, among which Fusobacterium nucleatum showed a close association with esophageal squamous cell carcinoma’s pathological stage and clinical stage. Frontiers Media S.A. 2023-05-19 /pmc/articles/PMC10235470/ /pubmed/37274313 http://dx.doi.org/10.3389/fcimb.2023.1145791 Text en Copyright © 2023 Zou, Feng, Cai, Qian and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Zou, Qian
Feng, Lijuan
Cai, Xunchao
Qian, Yun
Xu, Long
Esophageal microflora in esophageal diseases
title Esophageal microflora in esophageal diseases
title_full Esophageal microflora in esophageal diseases
title_fullStr Esophageal microflora in esophageal diseases
title_full_unstemmed Esophageal microflora in esophageal diseases
title_short Esophageal microflora in esophageal diseases
title_sort esophageal microflora in esophageal diseases
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235470/
https://www.ncbi.nlm.nih.gov/pubmed/37274313
http://dx.doi.org/10.3389/fcimb.2023.1145791
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