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Continuous pH monitoring using a sensor for the early detection of anastomotic leaks

Anastomotic leaks (AL) and staple line leaks are a serious post-operative complication that can develop following bariatric surgery. The delay in the onset of symptoms following a leak usually results in reactive diagnostics and treatment, leading to increased patient morbidity and mortality, and a...

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Autores principales: Huynh, Michelle, Tjandra, Ricky, Helwa, Nour, Okasha, Mohamed, El-Falou, Abdallah, Helwa, Youssef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235488/
https://www.ncbi.nlm.nih.gov/pubmed/37275781
http://dx.doi.org/10.3389/fmedt.2023.1128460
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author Huynh, Michelle
Tjandra, Ricky
Helwa, Nour
Okasha, Mohamed
El-Falou, Abdallah
Helwa, Youssef
author_facet Huynh, Michelle
Tjandra, Ricky
Helwa, Nour
Okasha, Mohamed
El-Falou, Abdallah
Helwa, Youssef
author_sort Huynh, Michelle
collection PubMed
description Anastomotic leaks (AL) and staple line leaks are a serious post-operative complication that can develop following bariatric surgery. The delay in the onset of symptoms following a leak usually results in reactive diagnostics and treatment, leading to increased patient morbidity and mortality, and a clinical and economic burden on both the patient and the hospital. Despite support in literature for pH as a biomarker for early detection of AL, the current methods of pH detection require significant clinician involvement and resources. Presented here is a polyaniline (PANI)-based pH sensor that can be connected inline to surgical drains to continuously monitor peritoneal secretion in real time for homeostatic changes in pH. During this study, the baseline peritoneal fluid pH was measured in two pigs using the PANI sensor and verified using a benchtop pH probe. The PANI sensor was then utilized to continuously monitor the changes in the pH of peritoneal effluent, as a gastric leak was simulated. The inline sensors were able to detect the resulting local changes in drainage pH within 10 min of leak induction. The successful implementation of this sensor in clinical practice can both enable high efficiency continuous monitoring of patient status and drastically decrease the time required to detect AL, thus potentially decreasing the clinical and economic burden incurred by gastric leaks.
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spelling pubmed-102354882023-06-03 Continuous pH monitoring using a sensor for the early detection of anastomotic leaks Huynh, Michelle Tjandra, Ricky Helwa, Nour Okasha, Mohamed El-Falou, Abdallah Helwa, Youssef Front Med Technol Medical Technology Anastomotic leaks (AL) and staple line leaks are a serious post-operative complication that can develop following bariatric surgery. The delay in the onset of symptoms following a leak usually results in reactive diagnostics and treatment, leading to increased patient morbidity and mortality, and a clinical and economic burden on both the patient and the hospital. Despite support in literature for pH as a biomarker for early detection of AL, the current methods of pH detection require significant clinician involvement and resources. Presented here is a polyaniline (PANI)-based pH sensor that can be connected inline to surgical drains to continuously monitor peritoneal secretion in real time for homeostatic changes in pH. During this study, the baseline peritoneal fluid pH was measured in two pigs using the PANI sensor and verified using a benchtop pH probe. The PANI sensor was then utilized to continuously monitor the changes in the pH of peritoneal effluent, as a gastric leak was simulated. The inline sensors were able to detect the resulting local changes in drainage pH within 10 min of leak induction. The successful implementation of this sensor in clinical practice can both enable high efficiency continuous monitoring of patient status and drastically decrease the time required to detect AL, thus potentially decreasing the clinical and economic burden incurred by gastric leaks. Frontiers Media S.A. 2023-05-19 /pmc/articles/PMC10235488/ /pubmed/37275781 http://dx.doi.org/10.3389/fmedt.2023.1128460 Text en © 2023 Huynh, Tjandra, Helwa, Okasha, El-Falou and Helwa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medical Technology
Huynh, Michelle
Tjandra, Ricky
Helwa, Nour
Okasha, Mohamed
El-Falou, Abdallah
Helwa, Youssef
Continuous pH monitoring using a sensor for the early detection of anastomotic leaks
title Continuous pH monitoring using a sensor for the early detection of anastomotic leaks
title_full Continuous pH monitoring using a sensor for the early detection of anastomotic leaks
title_fullStr Continuous pH monitoring using a sensor for the early detection of anastomotic leaks
title_full_unstemmed Continuous pH monitoring using a sensor for the early detection of anastomotic leaks
title_short Continuous pH monitoring using a sensor for the early detection of anastomotic leaks
title_sort continuous ph monitoring using a sensor for the early detection of anastomotic leaks
topic Medical Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235488/
https://www.ncbi.nlm.nih.gov/pubmed/37275781
http://dx.doi.org/10.3389/fmedt.2023.1128460
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