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Cardiomyopathy related desmocollin-2 prodomain variants affect the intracellular cadherin transport and processing

BACKGROUND: Arrhythmogenic cardiomyopathy can be caused by genetic variants in desmosomal cadherins. Since cardiac desmosomal cadherins are crucial for cell-cell-adhesion, their correct localization at the plasma membrane is essential. METHODS: Nine desmocollin-2 variants at five positions from vari...

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Detalles Bibliográficos
Autores principales:	Pohl, Greta Marie, Göz, Manuel, Gaertner, Anna, Brodehl, Andreas, Cimen, Tolga, Saguner, Ardan M., Schulze-Bahr, Eric, Walhorn, Volker, Anselmetti, Dario, Milting, Hendrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235514/ https://www.ncbi.nlm.nih.gov/pubmed/37273868 http://dx.doi.org/10.3389/fcvm.2023.1127261

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