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Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers

Actin is the most abundant and highly conserved cytoskeletal protein present in all eukaryotic cells. Remodeling of the actin cytoskeleton is controlled by a variety of actin-binding proteins that are extensively involved in biological processes such as cell motility and maintenance of cell shape. L...

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Autores principales: Wang, Xiaoxiao, Zhang, Chao, Song, Huangqin, Yuan, Junlong, Zhang, Xiaomin, Yuan, Yiran, Zhang, Lei, He, Jiefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235525/
https://www.ncbi.nlm.nih.gov/pubmed/37274282
http://dx.doi.org/10.3389/fonc.2023.1115943
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author Wang, Xiaoxiao
Zhang, Chao
Song, Huangqin
Yuan, Junlong
Zhang, Xiaomin
Yuan, Yiran
Zhang, Lei
He, Jiefeng
author_facet Wang, Xiaoxiao
Zhang, Chao
Song, Huangqin
Yuan, Junlong
Zhang, Xiaomin
Yuan, Yiran
Zhang, Lei
He, Jiefeng
author_sort Wang, Xiaoxiao
collection PubMed
description Actin is the most abundant and highly conserved cytoskeletal protein present in all eukaryotic cells. Remodeling of the actin cytoskeleton is controlled by a variety of actin-binding proteins that are extensively involved in biological processes such as cell motility and maintenance of cell shape. LIM domain and actin-binding protein 1 (LIMA1), as an important actin cytoskeletal regulator, was initially thought to be a tumor suppressor frequently downregulated in epithelial tumors. Importantly, the deficiency of LIMA1 may be responsible for dysregulated cytoskeletal dynamics, altered cell motility and disrupted cell-cell adhesion, which promote tumor proliferation, invasion and migration. As research progresses, the roles of LIMA1 extend from cytoskeletal dynamics and cell motility to cell division, gene regulation, apical extrusion, angiogenesis, cellular metabolism and lipid metabolism. However, the expression of LIMA1 in malignant tumors and its mechanism of action have not yet been elucidated, and many problems and challenges remain to be addressed. Therefore, this review systematically describes the structure and biological functions of LIMA1 and explores its expression and regulatory mechanism in malignant tumors, and further discusses its clinical value and therapeutic prospects.
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spelling pubmed-102355252023-06-03 Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers Wang, Xiaoxiao Zhang, Chao Song, Huangqin Yuan, Junlong Zhang, Xiaomin Yuan, Yiran Zhang, Lei He, Jiefeng Front Oncol Oncology Actin is the most abundant and highly conserved cytoskeletal protein present in all eukaryotic cells. Remodeling of the actin cytoskeleton is controlled by a variety of actin-binding proteins that are extensively involved in biological processes such as cell motility and maintenance of cell shape. LIM domain and actin-binding protein 1 (LIMA1), as an important actin cytoskeletal regulator, was initially thought to be a tumor suppressor frequently downregulated in epithelial tumors. Importantly, the deficiency of LIMA1 may be responsible for dysregulated cytoskeletal dynamics, altered cell motility and disrupted cell-cell adhesion, which promote tumor proliferation, invasion and migration. As research progresses, the roles of LIMA1 extend from cytoskeletal dynamics and cell motility to cell division, gene regulation, apical extrusion, angiogenesis, cellular metabolism and lipid metabolism. However, the expression of LIMA1 in malignant tumors and its mechanism of action have not yet been elucidated, and many problems and challenges remain to be addressed. Therefore, this review systematically describes the structure and biological functions of LIMA1 and explores its expression and regulatory mechanism in malignant tumors, and further discusses its clinical value and therapeutic prospects. Frontiers Media S.A. 2023-05-19 /pmc/articles/PMC10235525/ /pubmed/37274282 http://dx.doi.org/10.3389/fonc.2023.1115943 Text en Copyright © 2023 Wang, Zhang, Song, Yuan, Zhang, Yuan, Zhang and He https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Xiaoxiao
Zhang, Chao
Song, Huangqin
Yuan, Junlong
Zhang, Xiaomin
Yuan, Yiran
Zhang, Lei
He, Jiefeng
Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers
title Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers
title_full Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers
title_fullStr Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers
title_full_unstemmed Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers
title_short Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers
title_sort characterization of lima1 and its emerging roles and potential therapeutic prospects in cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235525/
https://www.ncbi.nlm.nih.gov/pubmed/37274282
http://dx.doi.org/10.3389/fonc.2023.1115943
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