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Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies
Suppression‐burst (SB) is an electroencephalographic pattern observed in neonatal‐ and infantile‐onset developmental and epileptic encephalopathies (DEEs), which are associated with high mortality in early life. However, the relation of SB electroencephalogram (SB‐EEG) with autonomic function requir...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235550/ https://www.ncbi.nlm.nih.gov/pubmed/36740266 http://dx.doi.org/10.1002/epi4.12705 |
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author | Yamamoto, Kaoru Baba, Shimpei Saito, Takashi Nakagawa, Eiji Sugai, Kenji Iwasaki, Masaki Fujita, Atsushi Fukuda, Hiromi Mizuguchi, Takeshi Kato, Mitsuhiro Matsumoto, Naomichi Sasaki, Masayuki |
author_facet | Yamamoto, Kaoru Baba, Shimpei Saito, Takashi Nakagawa, Eiji Sugai, Kenji Iwasaki, Masaki Fujita, Atsushi Fukuda, Hiromi Mizuguchi, Takeshi Kato, Mitsuhiro Matsumoto, Naomichi Sasaki, Masayuki |
author_sort | Yamamoto, Kaoru |
collection | PubMed |
description | Suppression‐burst (SB) is an electroencephalographic pattern observed in neonatal‐ and infantile‐onset developmental and epileptic encephalopathies (DEEs), which are associated with high mortality in early life. However, the relation of SB electroencephalogram (SB‐EEG) with autonomic function requires clarification. We investigated the relationship between heart rate (HR) and phasic transition during SB‐EEG in DEEs to explore the mechanism of early death. Seven patients (two with KCNT1‐DEE) with neonatal‐ and infantile‐onset DEE who presented with SB‐EEG were retrospectively identified. Five‐minute SB‐EEGs were analyzed with simultaneous recording of electrocardiograms. Mean HR, suppression duration, and burst period were calculated by measuring RR intervals. Two patients with KCNT1‐DEE exhibited synchronous HR fluctuations, with an HR decrease during suppression and an increase during burst. The HR decrease was larger (−6.1% and −7.7%) and the median duration of suppression was longer (4.0 and 8.2 s) in patients with KCNT1‐DEE than the other five (range: −2.9% to 0.9% and 0.7‐1.7s, respectively). A strong negative correlation was confirmed between suppression duration and HR reduction rates in one patient with KCNT1‐DEE. SB phases may influence HR regulation in patients with KCTN1‐DEE. |
format | Online Article Text |
id | pubmed-10235550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102355502023-06-03 Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies Yamamoto, Kaoru Baba, Shimpei Saito, Takashi Nakagawa, Eiji Sugai, Kenji Iwasaki, Masaki Fujita, Atsushi Fukuda, Hiromi Mizuguchi, Takeshi Kato, Mitsuhiro Matsumoto, Naomichi Sasaki, Masayuki Epilepsia Open Short Research Articles Suppression‐burst (SB) is an electroencephalographic pattern observed in neonatal‐ and infantile‐onset developmental and epileptic encephalopathies (DEEs), which are associated with high mortality in early life. However, the relation of SB electroencephalogram (SB‐EEG) with autonomic function requires clarification. We investigated the relationship between heart rate (HR) and phasic transition during SB‐EEG in DEEs to explore the mechanism of early death. Seven patients (two with KCNT1‐DEE) with neonatal‐ and infantile‐onset DEE who presented with SB‐EEG were retrospectively identified. Five‐minute SB‐EEGs were analyzed with simultaneous recording of electrocardiograms. Mean HR, suppression duration, and burst period were calculated by measuring RR intervals. Two patients with KCNT1‐DEE exhibited synchronous HR fluctuations, with an HR decrease during suppression and an increase during burst. The HR decrease was larger (−6.1% and −7.7%) and the median duration of suppression was longer (4.0 and 8.2 s) in patients with KCNT1‐DEE than the other five (range: −2.9% to 0.9% and 0.7‐1.7s, respectively). A strong negative correlation was confirmed between suppression duration and HR reduction rates in one patient with KCNT1‐DEE. SB phases may influence HR regulation in patients with KCTN1‐DEE. John Wiley and Sons Inc. 2023-02-14 /pmc/articles/PMC10235550/ /pubmed/36740266 http://dx.doi.org/10.1002/epi4.12705 Text en © 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Short Research Articles Yamamoto, Kaoru Baba, Shimpei Saito, Takashi Nakagawa, Eiji Sugai, Kenji Iwasaki, Masaki Fujita, Atsushi Fukuda, Hiromi Mizuguchi, Takeshi Kato, Mitsuhiro Matsumoto, Naomichi Sasaki, Masayuki Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies |
title | Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies |
title_full | Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies |
title_fullStr | Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies |
title_full_unstemmed | Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies |
title_short | Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies |
title_sort | synchronous heart rate reduction with suppression‐burst pattern in kcnt1‐related developmental and epileptic encephalopathies |
topic | Short Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235550/ https://www.ncbi.nlm.nih.gov/pubmed/36740266 http://dx.doi.org/10.1002/epi4.12705 |
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