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The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study

OBJECTIVE: We aimed to explore the underlying pathomechanisms of the comorbidity between three common systemic autoimmune disorders (SADs) [i.e., insulin‐dependent diabetes mellitus (IDDM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA)] and temporal lobe epilepsy (TLE), using bio...

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Autores principales: Malekpour, Mahdi, Salarikia, Seyed Reza, Kashkooli, Mohammad, Asadi‐Pooya, Ali A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235559/
https://www.ncbi.nlm.nih.gov/pubmed/36929812
http://dx.doi.org/10.1002/epi4.12727
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author Malekpour, Mahdi
Salarikia, Seyed Reza
Kashkooli, Mohammad
Asadi‐Pooya, Ali A.
author_facet Malekpour, Mahdi
Salarikia, Seyed Reza
Kashkooli, Mohammad
Asadi‐Pooya, Ali A.
author_sort Malekpour, Mahdi
collection PubMed
description OBJECTIVE: We aimed to explore the underlying pathomechanisms of the comorbidity between three common systemic autoimmune disorders (SADs) [i.e., insulin‐dependent diabetes mellitus (IDDM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA)] and temporal lobe epilepsy (TLE), using bioinformatics tools. We hypothesized that there are shared genetic variations among these four conditions. METHODS: Different databases (DisGeNET, Harmonizome, and Enrichr) were searched to find TLE‐associated genes with variants; their single nucleotide polymorphisms (SNPs) were gathered from the literature. We also did a separate literature search using PubMed with the following keywords for original articles: “TLE” or “Temporal lobe epilepsy” AND “genetic variation,” “single nucleotide polymorphism,” “SNP,” or “genetic polymorphism.” In the next step, the SNPs associated with TLE were searched in the LitVar database to find the shared gene variations with RA, SLE, and IDDM. RESULTS: Ninety unique SNPs were identified to be associated with TLE. LitVar search identified two SNPs that were shared between TLE and all three SADs (i.e., IDDM, SLE, and RA). The first SNP was rs16944 on the Interleukin‐1β (IL‐1β) gene. The second genetic variation was ε4 variation of apolipoprotein E (APOE) gene. SIGNIFICANCE: The shared genetic variations (i.e., rs16944 on the IL‐1β gene and ε4 variation of the APOE gene) may explain the underlying pathomechanisms of the comorbidity between three common SADs (i.e., IDDM, SLE, and RA) and TLE. Exploring such shared genetic variations may help find targeted therapies for patients with TLE, especially those with drug‐resistant seizures who also have comorbid SADs.
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spelling pubmed-102355592023-06-03 The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study Malekpour, Mahdi Salarikia, Seyed Reza Kashkooli, Mohammad Asadi‐Pooya, Ali A. Epilepsia Open Original Articles OBJECTIVE: We aimed to explore the underlying pathomechanisms of the comorbidity between three common systemic autoimmune disorders (SADs) [i.e., insulin‐dependent diabetes mellitus (IDDM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA)] and temporal lobe epilepsy (TLE), using bioinformatics tools. We hypothesized that there are shared genetic variations among these four conditions. METHODS: Different databases (DisGeNET, Harmonizome, and Enrichr) were searched to find TLE‐associated genes with variants; their single nucleotide polymorphisms (SNPs) were gathered from the literature. We also did a separate literature search using PubMed with the following keywords for original articles: “TLE” or “Temporal lobe epilepsy” AND “genetic variation,” “single nucleotide polymorphism,” “SNP,” or “genetic polymorphism.” In the next step, the SNPs associated with TLE were searched in the LitVar database to find the shared gene variations with RA, SLE, and IDDM. RESULTS: Ninety unique SNPs were identified to be associated with TLE. LitVar search identified two SNPs that were shared between TLE and all three SADs (i.e., IDDM, SLE, and RA). The first SNP was rs16944 on the Interleukin‐1β (IL‐1β) gene. The second genetic variation was ε4 variation of apolipoprotein E (APOE) gene. SIGNIFICANCE: The shared genetic variations (i.e., rs16944 on the IL‐1β gene and ε4 variation of the APOE gene) may explain the underlying pathomechanisms of the comorbidity between three common SADs (i.e., IDDM, SLE, and RA) and TLE. Exploring such shared genetic variations may help find targeted therapies for patients with TLE, especially those with drug‐resistant seizures who also have comorbid SADs. John Wiley and Sons Inc. 2023-03-22 /pmc/articles/PMC10235559/ /pubmed/36929812 http://dx.doi.org/10.1002/epi4.12727 Text en © 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Malekpour, Mahdi
Salarikia, Seyed Reza
Kashkooli, Mohammad
Asadi‐Pooya, Ali A.
The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study
title The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study
title_full The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study
title_fullStr The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study
title_full_unstemmed The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study
title_short The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study
title_sort genetic link between systemic autoimmune disorders and temporal lobe epilepsy: a bioinformatics study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235559/
https://www.ncbi.nlm.nih.gov/pubmed/36929812
http://dx.doi.org/10.1002/epi4.12727
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