Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs

The neurosteroid allopregnanolone (ALLO) is under investigation as a treatment for benzodiazepine‐refractory status epilepticus (SE). Here, we assess the cardiopulmonary safety of intravenous ALLO by itself and after a clinically recommended dose of midazolam (MDZ) in two healthy adult beagles. Each...

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Detalles Bibliográficos
Autores principales: Bruun, Donald A., Ma, Betty, Chen, Yi‐Je, Wu, Chun‐Yi, Aleman, Monica, Zolkowska, Dorota, Smiley‐Jewell, Suzette M., Rogawski, Michael A., Lein, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235566/
https://www.ncbi.nlm.nih.gov/pubmed/36919379
http://dx.doi.org/10.1002/epi4.12723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235566/
https://www.ncbi.nlm.nih.gov/pubmed/36919379
http://dx.doi.org/10.1002/epi4.12723

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